间充质干细胞用于牙周再生临床疗效的系统评价与Meta分析  

Clinical efficacy of mesenchymal stem cells on periodontal regeneration:a systematic review and meta-analysis

作　　者：李天元 朱彤欣 柳庆 董迎春[3] 陈斌[2] Li Tianyuan;Zhu Tongxin;Liu Qing;Dong Yingchun;Chen Bin(Dept.of Stomatology,the 904th Hospital of Joint Logistics Unit of the Chinese People’s Liberation Army,Changzhou 213000,China;Dept.of Periodontology,Nanjing Stomatological Hospital,Medical School of Nanjing University,Re‐search Institute of Stomatology,Nanjing University,Nanjing 210008,China;Dept.of Anesthesiology,Nanjing Stomato‐logical Hospital,Medical School of Nanjing University,Research Institute of Stomatology,Nanjing University,Nanjing 210008,China)

机构地区：[1]中国人民解放军联勤保障部队第九〇四医院口腔科,常州213000 [2]南京大学医学院附属口腔医院(南京市口腔医院)牙周病科、南京大学口腔医学研究所,南京210008 [3]南京大学医学院附属口腔医院(南京市口腔医院)麻醉科、南京大学口腔医学研究所,南京210008

出　　处：《国际口腔医学杂志》2025年第3期296-307,共12页International Journal of Stomatology

基　　金：国家自然科学基金(82401135);江苏省自然科学基金(BK20220199);南京市卫生科技发展专项资金(ZKX22054)。

摘　　要：目的通过Meta分析比较使用与不使用间充质干细胞(MSC)的牙周手术患者在临床附着水平(CAL)、牙周探诊深度(PPD)、牙龈退缩(GR)和骨缺损深度(BDD)上的差异,评估MSC在牙周再生中的临床疗效。方法在PubMed、Cochrane Library、Embase、Scopus、中国知网、万方数据和中国生物医学文献网数据库中,检索2024年4月1日以前使用MSC治疗牙周炎患者牙周缺损的随机对照研究。由两位研究者进行文献筛选、数据资料提取,并评估纳入研究的偏倚风险。采用RevMan 5.4与Stata 15.1软件进行数据分析。结果Meta分析共纳入6项研究,结果显示:与对照组相比,MSC治疗组有更明显的CAL改善、PPD减少和BDD降低(P<0.05);但在GR指标上,两组疗效的差异无统计学意义(P>0.05)。结论与传统的牙周再生方法相比,应用MSC可能具有一定优势;但由于研究间的潜在异质性以及纳入研究数量及质量的限制,应审慎看待该结论。未来仍需大样本、多中心的高质量随机对照临床试验进一步评估MSC应用于牙周再生的临床疗效。Objective This study aimed to compare the differences in clinical attachment level(CAL),periodontal probing depth(PPD),gingival recession(GR),and bone defect depth(BDD)between patients undergoing periodontal sur‐geries with and without mesenchymal stem cells(MSCs)and to evaluate the clinical efficacy of MSCs in periodontal re‐generation through a meta-analysis.Methods PubMed,Cochrane Library,Embase,Scopus,CNKI,Wanfang Data,and CBM were comprehensively searched for randomized controlled studies(RCTs)about MSC therapy for perio-dontal defects in patients with periodontitis up to April 1,2024.Literature selection,data collection,and evalua‐tion of bias were conducted by two researchers indepen‐dently,and then data were analyzed through RevMan 5.4 software and Stata 15.1 software.Results Six studies were enrolled.The meta-analysis results showed that the ex‐perimental group had more significant improvement in CAL and decrease in PPD and BDD(P<0.05).However,no signi-ficant difference was found in efficacy between the two groups in terms of GR(P>0.05).Conclusion Compared with traditional periodontal regeneration methods,the application of MSCs may have some advantages.However,potential he-terogeneity among the included RCTs and limitations on the quantity and quality of these studies necessitate cautious inter‐pretation of the findings.Further high-quality RCTs with a large sample size and a multicentral character are required to prove the efficacy of MSCs in periodontal regeneration.

关 键 词：间充质干细胞 牙周再生 牙周炎 牙槽骨丧失 

分 类 号：R781.4[医药卫生—口腔医学]