牙龈卟啉单胞菌影响血管平滑肌细胞调节性细胞死亡及表型转换的研究进展  

Research progress into the effects of Porphyromonas gingivalis on regulatory cell death and phenotypic switching of vascular smooth muscle cells

作　　者：别梦瑶 周婕妤 吴亚菲[1] 赵蕾[1] Bie Mengyao;Zhou Jieyu;Wu Yafei;Zhao Lei(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Dept.of Periodontology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院牙周病科,成都610041

出　　处：《国际口腔医学杂志》2025年第3期308-316,共9页International Journal of Stomatology

基　　金：国家自然科学基金(81970944);国家自然科学基金青年科学基金(82301089);四川大学华西口腔医院探索与研发项目(RD-02-202407)。

摘　　要：牙周炎是由细菌感染引起的慢性炎症性疾病。流行病学和体内外研究均表明牙周炎与心血管疾病风险增加密切相关。血管平滑肌细胞通过自噬、凋亡、焦亡等调节性细胞死亡和表型转换参与动脉粥样硬化、主动脉瘤、血管钙化等心血管疾病的发生发展。牙龈卟啉单胞菌是最重要的牙周致病菌之一,已被证明可以改变血管平滑肌细胞的生物学行为,不仅能侵入血管平滑肌细胞影响其调节性细胞死亡的过程,还能促进其增殖、迁移、钙化等表型转换,在心血管疾病的发生发展中发挥重要作用。本文旨在梳理相关研究进展,以期揭示牙周炎和血管平滑肌细胞调节性细胞死亡及其表型转换之间的联系,为更好地防治牙周炎和心血管疾病提供思路。Periodontitis is a chronic inflammatory disease caused by bacterial infection.Epidemiological studies and in vivo/in vitro research have consistently demonstrated a strong association between periodontitis and an increased risk of cardiovascular diseases.Vascular smooth muscle cells(VSMCs)participate in the pathogenesis of atherosclerosis,aortic aneurysms,and vascular calcification via regulated cell death mechanisms(including autophagy,apoptosis,and pyropto‐sis)and phenotypic switching.Porphyromonas gingivalis,a critical periodontal pathogen,alters VSMC biological beha-vior,not only invading VSMCs to influence their regulated cell death process but also promoting phenotypic switching characterized by proliferation,migration,and calcification.These mechanisms play pivotal roles in cardiovascular disease development.This review aims to synthesize recent re‐search advances and elucidate the connections between periodontitis and VSMC-regulated cell death/phenotypic switching.Novel insights into improved prevention and treatment strategies for periodontitis and cardiovascular diseases are provided.

关 键 词：牙龈卟啉单胞菌 血管平滑肌细胞 心血管疾病 表型转换 牙周炎 

分 类 号：R780.2[医药卫生—口腔医学]