竞争性内源性RNA在牙周炎中的作用及机制的研究进展  

Research progress on the role and mechanism of competitive endogenous RNA in periodontitis

作　　者：范兴丽 潘乐 赵家园 项秋猛 陈启林 Fan Xingli;Pan Le;Zhao Jiayuan;Xiang Qiumeng;Chen Qilin(Dept.of Stomatology,Taihe Hospital of Hubei University of Medicine,Institute of Oral Diseases,School of Stomatology,Hubei University of Medicine,Shiyan 442000,China)

机构地区：[1]湖北医药学院附属太和医院口腔医学中心、湖北医药学院口腔医学院口腔疾病研究所,十堰442000

出　　处：《国际口腔医学杂志》2025年第3期317-322,共6页International Journal of Stomatology

基　　金：湖北省卫生健康委科研项目(WJ2021M049);2022年度湖北省教育厅科学研究计划指导性项目(B2022499)。

摘　　要：竞争性内源性RNA (ceRNA)可以通过转录调节炎症相关介质的反应进而调控牙周炎的进展。ceRNA,包括长链非编码RNA、环状RNA、信使RNA等,可与微小RNA结合,构成ceRNA网络,调控下游靶基因的表达,影响牙周炎的发生、发展。本文总结了已经通过实验验证的ceRNA在调控牙周炎发生发展中的作用及机制,对包括抑制和促进牙周炎发生发展两个方面的研究进展进行综述,为未来牙周炎的研究提供新思路。Research has found that competitive endogenous RNA(ceRNA)regulates the progression of periodontitis by modulating the transcriptional response of inflammation-related mediators.ceRNA,including long noncoding RNA,circular RNA,and messenger RNA,can bind to microRNA to form a ceRNA network,regulate the expression of down‐stream target genes,and influence the occurrence and development of periodontitis.This article summarizes the role and mechanism of ceRNA in regulating the occurrence and development of periodontitis that have been verified by experimen‐tal evidence.This article also reviews the research progress in inhibiting and promoting the occurrence and development of periodontitis,and provides new ideas for future research on periodontitis.

关 键 词：竞争性内源性RNA 牙周炎 微小RNA 长链非编码RNA 环状RNA 

分 类 号：R781.4[医药卫生—口腔医学]