吲哚菁绿荧光显影技术在口腔鳞状细胞癌手术治疗中的应用进展  

Progress of research on the application of indocyanine green fluorescence imaging technology in the surgical treatment of oral squamous cell carcinoma

作　　者：买克里亚·艾克帕尔 买买提吐逊·吐尔地[1,2] Maikeiya Aikepaer;Maimaitituxun Tuerdi(Dept.of Oral and Maxillofacial Trauma and Orthognathic Surgery,First Affiliated Hospital(Stomatological Hospital)of Xinjiang Medical University,Urumqi 830054,China;Institute of Stomatology,Xinjiang Uygur Autonomous Region,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院(附属口腔医院)口腔颌面创伤正颌外科,乌鲁木齐830054 [2]新疆维吾尔自治区口腔医学研究所,乌鲁木齐830054

出　　处：《国际口腔医学杂志》2025年第3期405-410,共6页International Journal of Stomatology

基　　金：国家自然科学基金(82360198)。

摘　　要：目前,口腔鳞状细胞癌(OSCC)的手术切除多依赖于临床医生的经验如视诊、触诊及术前影像学检查为参考,缺乏术中实时且客观的评估方法。吲哚菁绿(ICG)作为一种安全且无污染的有机荧光染料,在近红外荧光(NIR)的照射下,聚集在病变部位并显影。此技术应用于OSCC的原发灶及周围血管和神经的显影、前哨淋巴结活检、颈部淋巴结清扫、修复重建中游离皮瓣血运状态的评估等多方面。NIR显影技术未来或许会成为OSCC的早期诊断和精准治疗中关键的一环,本文将以ICG-NIR在OSCC中的应用进行综述。The surgical resection of oral squamous cell carcinoma(OSCC)mostly relies on the experience of clini‐cians,such as visual examination,palpation,and preoperative imaging examination.Real-time and objective intraopera‐tive evaluation methods are also lacking.Indocyanine green(ICG)is a safe and pollution-free organic fluorescent dye that accumulates and develops at a lesion under near-infrared(NIR)fluorescence.This technique can be applied in the visua-lization of primary tumors and surrounding blood vessels and nerves,sentinel lymph-node biopsy,cervical lymph-node dissection,and the evaluation of free-flap blood supply for the repair and reconstruction of OSCC.NIR imaging technolo‐gy may become a key link in the early diagnosis and precise treatment of OSCC in the future.This article reviews the ap‐plication of ICG-NIR in OSCC.

关 键 词：吲哚菁绿 近红外荧光显影技术 口腔鳞状细胞癌 

分 类 号：R739.8[医药卫生—肿瘤]