水相中苯甲醇“一锅煮”微波合成苄基芳基醚  

One-pot Microwave Synthesis of Benzyl Aryl Ethers from Benzyl Alcohol in Aqueous Phase

作　　者：刘心茹 王豪 徐菁 张首国 刘曙晨 彭涛 LIU Xinru;WANG Hao;XU Jing;ZHANG Shouguo;LIU Shuchen;PENG Tao(Academy of Military Medical Sciences,Beijing 100850,China)

机构地区：[1]军事医学研究院,北京100850

出　　处：《合成化学》2025年第3期145-152,共8页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21272273)。

摘　　要：绿色合成和高效合成是有机合成的发展方向,酚类化合物的苄基化反应广泛应用于实验室生物活性分子的合成中,发展绿色、高效的苄基化反应方法具有重要意义。以苯甲醇和氢溴酸水溶液为原料微波反应合成溴化苄,然后向反应混合物中加入取代酚、四丁基碘化铵和碳酸钾,微波反应“一锅煮”合成了20个苄基芳基醚类化合物(2a~2t,2D),其结构经^(1)H NMR和^(13)C NMR表征,产率可达81.6%以上。本方法为酚类化合物的苄基化反应提供了一种绿色、低毒、高效的实验室合成方法。Green synthesis and efficient synthesis are the development directions of organic synthesis.The benzylation of phenolic compounds is widely used in the synthesis of bioactive molecules in the laboratory,and the development of green and efficient benzylation methods is of great significance.Using benzyl alcohol and hydrobromic acid aqueous solution as raw materials,benzyl bromide was synthesized by microwave reaction.Then,substituted phenols,tetrabutylammonium iodide,and potassium carbonate were added to the reaction mixture,and 20 benzyl aryl ether compounds(2a~2t)were synthesized by one pot microwave synthesis.The products were characterized by ^(1)H NMR and ^(13)C NMR,and their yields reached over 81.6%.This method provides a green,low toxicity,and efficient laboratory synthesis method for the benzylation of phenolic compounds.

关 键 词：微波合成 苄基化 酚 一锅煮 合成 

分 类 号：R914.5[医药卫生—药物化学]