Liquid biopsies in psychiatric disorders:Identifying peripheral biomarkers of brain health  

作　　者：Jennifer L.Payne Sarven Sabunciyan 

机构地区：[1]Department of Psychiatry and Neurobehavioral Sciences,University of Virginia,Charlottesville,VA,USA [2]Department of Pediatrics,Johns Hopkins School of Medicine,Baltimore,MD,USA

出　　处：《Neural Regeneration Research》2026年第2期691-692,共2页中国神经再生研究(英文版)

基　　金：supported by Department of Defense grant HT9425-24-1-0030 a grant from the Stanley Medical Research Institute(to SS).

摘　　要：The inability to access brain tissue has greatly hindered our ability to study and care for individuals suffering from psychiatric and neurological conditions.Critics have questioned efforts to develop peripheral blood biomarkers in neurological and psychiatric disorders based on the assertion that disease pathology is limited to the brain.The discovery that all tissues,including the brain,release extracellular vesicles(Raposo and Stoorvogel,2013)and cell free DNAs(Chan et al.,2013)into various body fluids has provided a potential way to measure activity from inaccessible tissues like the central nervous system(CNS)and has given rise to the term“liquid biopsy.”The development of liquid biopsies that can diagnose and predict the course of psychiatric and neurological disorders would be transformative.The ability to predict episodic events such as mania,depression,and risk for suicide would be particularly useful for psychiatric care as it would enable the development of interventions that prevent mortality and improve outcomes.Additionally,biomarkers that are informative about drug response and aid in treatment decisions would be a significant advance in psychiatric care as it would prevent patients from having to endure multiple courses of ineffective treatments and side effects.

关 键 词：develop peripheral blood biomarkers liquid biopsies study care individuals cell free dnas chan extracellular vesicles raposo body fluids neurological psychiatric disorders peripheral biomarkers 

分 类 号：R749[医药卫生—神经病学与精神病学]