异甘草酸镁联合熊去氧胆酸对肝损害患者的疗效及免疫炎症反应的影响  

Effect of Magnesium Isoglycyrrhizinate Combined with Ursodeoxycholic Acid on Immune and Inflammatory Response in Patients with Liver Damage

作　　者：练君兰 LIAN Junlan(Infection Department,Changzhou Jintan first People's Hospital,Changzhou,Jiangsu 213200)

机构地区：[1]常州市金坛第一人民医院感染科,江苏常州213200

出　　处：《智慧健康》2025年第4期42-45,共4页Smart Healthcare

摘　　要：目的 探讨异甘草酸镁联合熊去氧胆酸对肝损害的疗效及对免疫炎症反应的影响。方法 选取2022年1月—2024年3月本院收治的药物性肝损害患者76例为研究对象,使用随机数字编号法将其分为两组。对照组使用异甘草酸镁治疗,观察组联合使用异甘草酸镁与熊去氧胆酸治疗。两组均接受4周的治疗,比较治疗前、后两组的肝功能及免疫炎症反应,统计并比较两组患者的恢复时间。结果 干预4周后,两组的谷丙转氨酶(ALT)水平、谷草转氨酶(AST)水平及总胆红素(TBIL)水平均较干预前有所下降;且观察组均低于对照组(P<0.05)。干预4周后,两组肿瘤坏死因子α(TNF-α)水平和白介素-6(IL-6)水平均低于对照组,白介素-10(IL-10)水平高于对照组(P<0.05)。观察组恶心消失时间、食欲恢复时间、乏力消失时间、腹泻消失时间均短于对照组(P<0.05)。结论 异甘草酸镁联合熊去氧胆酸有助于减轻肝损伤患者的免疫炎症反应,增强其肝功能,整体治疗效果显著,值得大力推广应用。Objective Purpose To investigate the effect of magnesium isoglycyrrhizate combined with ursodeoxycholic acid on liver damage and immune inflammatory response.Methods 76 patients with drug-induced liver damage were enrolled and grouped by random number numbering method.Magnesium isoglycyrrhizinate was used in the control group.Observation group using different glycyrrhizic acid magnesium jointly bear bile acid to oxygen,accept 4 weeks of treatment.The liver function and immune inflammatory reaction before and after treatment were compared,and the recovery time of the two groups was statistically compared.Results After the intervention,the ALT,AST and TBIL values of the two groups were lower than before.The values of ALT,AST and TBIL in the observation group were lower than those in the control group 4 weeks after intervention,with statistical differences(P<0.05).After 4 weeks of intervention,the levels of TNF-αand IL-6 in the two groups were lower than those in the control group,and the level of IL-10 was higher than that in the control group.Improve significantly in the control group and observation group,with statistical significance(P<0.05).The disappearance time of nausea,appetite recovery time,fatigue disappearance time and diarrhea disappearance time in observation group were less than those in control group(P<0.05).Conclusion Magnesium isoglycyrrhizinate combined with ursodeoxychoic acid can help to reduce the immune and inflammatory reaction of patients with liver injury and improve liver function.Its overall application effect is remarkable,which is worth promoting.

关 键 词：异甘草酸镁 熊去氧胆酸 药物性肝损害 免疫炎症反应 

分 类 号：R575[医药卫生—消化系统]