宏基因组二代测序技术诊治淋巴瘤相关噬血细胞综合征继发耶氏肺孢子菌肺炎1例并文献复习  

Analysis of Metagenomic Next-Generation Sequencing in Clinical Diagnosis and Treatment of Pneumocystis Jirovecii Pneumonia of Lymphoma Associated Hemophagocytic Syndrome Patient:A Case Report and Literature Review

作　　者：王雯欣 刘梦琳 王英慧[1] 赵晶[1] 崔翰文[1] WANG Wenxin;LIU Menglin;WANG Yinghui;ZHAO Jing;CUI Hanwen(Heilongjiang Provincial Hospital,Harbin,Heilongjiang 150036)

机构地区：[1]黑龙江省医院,黑龙江哈尔滨150036

出　　处：《智慧健康》2025年第4期63-65,69,共4页Smart Healthcare

基　　金：黑龙江省卫生健康委科研课题项目《调节T细胞及细胞因子在难治免疫性血小板减少症中的研究》(项目编号:20210303040142)。

摘　　要：耶氏肺孢子菌肺炎(pneumocystis jirovecii pneumonia,PJP)在免疫力低下者中常见,临床及影像学表现不典型,诊治困难。然而,在噬血细胞综合征患者中鲜有报道。本文报告1例淋巴瘤相关噬血细胞综合征患者通过宏基因组二代测序技术精准诊治的经过,并进行文献复习,以提高对该病的认识,为该病的早诊早治提供思路。Pneumocystis pneumonia(PJP)is a common pneumonia in immunocompromised patients with atypical clinical and imaging manifestations and difficult diagnosis and treatment.However,it is rarely reported in patients with hemophagocytic syndrome.In this paper,metagenomic second-generation sequencing technology was used to accurately diagnose and treat 1 patient with lymphoma-associated hemophagocytic syndrome,and literature review was conducted to improve the understanding of the disease and provide ideas for early diagnosis and treatment of the disease.

关 键 词：淋巴瘤 噬血细胞综合征 耶氏肺孢子菌肺炎 宏基因组二代测序 

分 类 号：R733.4[医药卫生—肿瘤]