抗寄生虫药物治疗恶性肿瘤的相关研究进展  

Research progress of antiparasitic drugs for malignant tumor treatment

作　　者：杨柳 周诗婕 高文仓 YANG Liu;ZHOU Shijie;GAO Wencang(The Second Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310005,China;不详)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江中医药大学附属第二医院肿瘤内科,浙江杭州310005

出　　处：《中华全科医学》2025年第5期840-843,共4页Chinese Journal of General Practice

基　　金：“白求恩·肿瘤临床研究计划”项目(BCF-XD-ZL-20220118-032);浙江省中医药科技计划项目(2021ZB127,2018ZB064)。

摘　　要：恶性肿瘤是世界范围内威胁人类寿命和健康的元凶之一。肿瘤广泛转移引起的多器官衰竭、继发感染、大出血以及免疫系统的抑制导致恶性肿瘤的死亡率高居第2位。现阶段恶性肿瘤的治疗模式以传统的手术治疗、化学治疗、放射治疗为主,辅以新型的免疫治疗、靶向治疗,存在着治疗不彻底、易转移和复发、不良反应多等缺点。寄生虫类疾病同样是严重危害人类健康的疾病,具有严重破坏性且十分普遍的传染性,每年造成数百万人发病和死亡,其中以蛔虫、弓形虫和蠕虫感染较为多见。据报道,全球约70%的人口曾感染蛔虫;约30%~50%的人口曾感染弓形虫;约16%的人口曾感染蠕虫。寄生虫进入人体后进一步感染呼吸系统、消化系统甚至神经系统,严重时引起脑膜炎、心肌炎等并发症,导致器官功能衰竭甚至死亡。近年来,随着对寄生虫相关疾病研究的不断深入,已经证实寄生虫感染与恶性肿瘤发生、发展之间存在着密切关系。寄生虫可以通过直接感染和间接诱导促进恶性肿瘤的发生、进展、转移。基于此,国内外学者对抗寄生虫药物的抗肿瘤特性进行了广泛研究,抗寄生虫药物有望实现“再利用”,作为恶性肿瘤的新型治疗手段用于临床。本文总结了近年来抗寄生虫药物治疗恶性肿瘤的相关研究进展,旨在为恶性肿瘤提供更多安全有效的治疗方案。Malignant tumors are one of the culprits threatening human lifespan and health worldwide.The mortality rate of malignant tumors ranks second due to multiple organ failure,secondary infections,massive bleeding,and immune system suppression caused by widespread tumor metastasis.At present,the treatment mode of malignant tumors mainly relies on traditional surgical treatment,chemotherapy,and radiation therapy,supplemented by newer types such as immunotherapy and targeted therapy.However,there are disadvantages such as incomplete tumor eradication,high risk metastasis and recurrence,and multiple adverse reactions.Parasitic diseases are also serious threats to human health,with severe destructive and widespread infectivity,causing millions of illnesses and deaths every year.Common parasitic infections include roundworm,Toxoplasma gondii,and other helminths.According to reports,about 70%of the global population has been infected with roundworms,about 30%-50%with Toxoplasma gondii,about 16%with other parasitic worms.Once inside the human body,parasites can spread to the respiratory,digestive,and even nervous systems,potentially cause complications such as meningitis and myocarditis,which may lead to organ failure and even death.In recent years,extensive research on parasitic diseases has confirmed a strong relationship between parasitic infections and the occurrence and development of malignant tumors.Parasites can promote the occurrence,progression,and metastasis of malignant tumors through direct both infection and indirect induction.Based on this,scholars worldwide have conducted extensive research on the anti-tumor properties of antiparasitic drugs.These antiparasitic drugs are expected to be promising for malignant tumors for clinical use.This article summarizes the research progress of antiparasitic drugs in the treatment of malignant tumors in recent years,aiming to provide safer and more effective treatment options for malignant tumors.

关 键 词：抗寄生虫药物 恶性肿瘤 作用机制 药物再利用 

分 类 号：R730.5[医药卫生—肿瘤] R978.6[医药卫生—临床医学]