重型肝炎与肝炎后肝硬化合并感染患者应用免疫治疗的临床效果观察  

Observe the Clinical Effects of Immunotherapy in Patients with Hepatitis and Hepatitis and Hepatitis

作　　者：何娟 HE Juan(Changsha No.1 Hospital Infection Department 1 Disease Area,Changsha,Hunan 410006)

机构地区：[1]长沙市第一医院感染科一病区,湖南长沙410006

出　　处：《智慧健康》2025年第5期100-103,共4页Smart Healthcare

摘　　要：目的 探究免疫疗法在治疗重症肝炎以及肝炎后肝硬化并感染病症中的临床疗效。方法 选择2022年6月—2024年6月本院收治的60例重型肝炎以及肝炎后肝硬化合并感染患者为研究对象,并随机将其分成对照组与实验组,每组30例患者。其中,对照组给予常规治疗,实验组在常规治疗基础上采取免疫治疗,观察两组的治疗效果。结果 实验组治疗后感染控制率高于对照组(P<0.05);实验组上消化道出血、肝性脑病、肝肾综合征及死亡率均比对照组低(P<0.05);治疗后,两组患者的CRP、PCT、WBC和TNF-α水平均较治疗前下降,且实验组的下降程度显著优于对照组(P<0.05)。治疗前后,两组患者的白蛋白水平、凝血酶原时间、总胆红素、总胆固醇和丙氨酸氨基转移酶的平均值变化不大(P>0.05)。结论 免疫治疗方法在重型肝炎后肝硬化合并感染治疗中能够显著控制感染率,减少并发症,同时还可显著改善炎症因子水平和肝功能指标,应用价值高。Objective To explore the clinical efficacy of immunotherapy in the treatment of severe hepatitis and hepatitis after hepatitis.Methods Choose 60 cases of severe hepatitis after June 2022 to June 2024.Patients with liver cirrhosis and infection in this group were randomly divided into the control group and experimental group,each of which was given conventional treatment.The experimental group adopted immunotherapy on the basis of conventional treatment to observe the treatment effects of the two groups.Results The infection rate of the infection after the treatment group was 86.67%,and the control group was 60.00%(P<0.05);the gastrointestinal bleeding,hepatic encephalopathy,liver and kidney syndrome,and mortality rate were lower than the control group,and P<0.05;After treatment,the levels of CRP,PCT,WBC,and TNF-α of the two groups of patients decreased compared with pre-treatment,and the degree of decline in the experimental group was significantly better than the control group (P<0.05).Before and after treatment,the average change of albumin levels,original time,total bilirubin,total cholesterol,and alanine aminotransferase of the two groups of patients did not change much (P>0.05).Conclusion Immunotherapy methods can significantly control the infection rate in the treatment of hepatitis after severe hepatitis,reduce complications,and also significantly improve the level of inflammatory factors and liver function indicators,and high application value.

关 键 词：免疫治疗 重型肝炎 肝炎后肝硬化 感染 

分 类 号：R575[医药卫生—消化系统]