清热祛湿方联合锡类散灌肠治疗轻中度大肠湿热证溃疡性结肠炎的效果观察  

Observation on the Efficacy of Enema with Qingre Qushi Recipe Combined with Xilei Powder in the Treatment of Mild to Moderate Damp-Heat Syndrome of Ulcerative Colitis

作　　者：黄婷婷 唐伟[1] 陈久红[1] 孙长代 HUANG Tingting;TANG Wei;CHEN Jiuhong;SUN Changdai(Department of Gastroenterology,Lu'an Hospital of Traditional Chinese Medicine,Lu'an,Anhui 237005,China)

机构地区：[1]六安市中医院消化内科,安徽六安237005

出　　处：《临床误诊误治》2025年第9期92-96,共5页Clinical Misdiagnosis & Mistherapy

基　　金：安徽省中医药传承创新科研项目(2020zcyb24)。

摘　　要：目的 探讨清热祛湿方联合锡类散灌肠治疗轻中度大肠湿热证溃疡性结肠炎(UC)的疗效。方法 回顾性分析2021年1月至2023年1月收治的UC患者76例,根据治疗方式分为观察组和对照组各38例。观察组实施清热祛湿方联合锡类散灌肠治疗,对照组实施美沙拉嗪纳肛治疗。比较2组患者临床疗效、肠黏膜损伤改善程度、临床症状改善程度、炎症水平、不良反应发生率及复发率。结果 观察组总有效率[94.74%(36/38)]高于对照组[92.11%(35/38)],但差异无统计学意义(P>0.05)。治疗后,2组Baron、Mayo评分及C反应蛋白、肿瘤坏死因子-α、白细胞介素-8均较治疗前降低(P<0.05)。2组里急后重、腹泻、黏液脓血便评分均较治疗前降低,且观察组里急后重评分低于对照组(P<0.05)。观察组不良反应发生率[7.89%(3/38)]、复发率[2.63%(1/38)]均低于对照组[26.32%(10/38)、15.79%(6/38)],差异有统计学意义(P<0.05)。结论 清热祛湿方联合锡类散灌肠治疗UC与常规西药疗效相当,能减轻炎症,有效改善患者肠黏膜损伤、临床症状,降低不良反应发生率及复发率。Objective To investigate the efficacy of enema with Qingre Qushi recipe combined with Xilei powder in the treatment of mild to moderate ulcerative colitis(UC).Methods The general data of 76 patients with UC admitted from January 2021 to January 2023 were retrospectively analyzed.According to the treatment methods,they were divided into observation group and control group,with 38 patients in each group.The observation group was treated with enema with Qingre Qushi recipe combined with Xilei powder,and the control group was treated with Mesalazine administered rectally.The clinical efficacy,the improvement of intestinal mucosal injury,the improvement of clinical symptoms,the level of inflammation,the incidence of adverse reactions and the recurrence rate were compared between the two groups.Results The total effective rate in the observation group [94.74%(36/38)] was higher than that in the control group [92.11%(35/38)],but the difference was not significant(P>0.05).After treatment,the Baron and Mayo scores,C reactive protein,tumor necrosis factor-α,and interleukin-8 in the two groups were lower than those before treatment(P<0.05).The scores of tenesmus,diarrhea and mucopurulent and bloody stool in the two groups were lower than those before treatment,and the score of tenesmus in the observation group was lower than that in the control group(P<0.05).The incidence of adverse reactions [7.89%(3/38)] and the recurrence rate [2.63%(1/38)] were lower in the observation group than in the control group [26.32%(10/38),15.79%(6/38)],showing significant difference(P<0.05).Conclusion Enema with Qingre Qushi recipe combined with Xilei powder has the same efficacy as conventional western medicine in the treatment of UC,which can reduce inflammation,effectively improve intestinal mucosal injury and clinical symptoms,and reduce the incidence of adverse reactions and recurrence rate.

关 键 词：结肠炎 溃疡性 清热祛湿方 锡类散 Baron评分 Mayo评分 C反应蛋白 里急后重 预后 

分 类 号：R574.62[医药卫生—消化系统]