基于功能磁共振信号实时神经反馈技术在精神障碍中研究进展  

The application of real-time neurofeedback interventions based on functional magnetic resonance imaging signals in mental disorders

作　　者：刘思言 王继军[1] LIU Siyan;WANG Jijun(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030

出　　处：《中国神经精神疾病杂志》2025年第3期174-179,共6页Chinese Journal of Nervous and Mental Diseases

摘　　要：实时功能磁共振成像神经反馈是一种无创神经调控技术,通过实时监测和反馈大脑活动,帮助个体自我调节脑功能。该技术包括传统神经反馈、解码神经反馈和基于功能连接的神经反馈,应用于如重性抑郁障碍、强迫症、Tourette综合征、物质成瘾、精神分裂症等精神障碍的治疗。然而,目前研究方法、反馈算法和目标靶点的差异影响了研究的可靠性和可重复性。未来研究应优化研究设计,明确最佳神经靶点,评估长期疗效,以提升实时功能磁共振成像神经反馈在精神疾病治疗中的应用价值。Real-time functional magnetic resonance imaging neurofeedback is a non-invasive neuromodulation technique that helps individuals self-regulate brain function by real-time monitoring and feedback of brain activity.This technique includes traditional neurofeedback,decoding neurofeedback,and connectivity-based neurofeedback,and has been applied in the treatment of psychiatric disorders such as major depressive disorder,obsessive-compulsive disorder,Tourette syndrome,substance addiction,and schizophrenia.However,differences in research methods,feedback algorithms,and target areas have a big impact on the reliability and reproducibility of studies.Future research should optimize experimental designs,clarify the best neural targets,and assess long-term efficacy to enhance the clinical application of real-time fMRI neurofeedback in the treatment of psychiatric diseases.

关 键 词：功能磁共振成像 精神障碍 神经反馈 生物反馈 神经调控 脑功能 神经可塑性 

分 类 号：R749[医药卫生—神经病学与精神病学]