数字活检在肿瘤精准诊断中的研究进展  

Research Progress of Digital Biopsy for Precision Diagnosis of Tumors

作　　者：罗丽萍 王卫东[2] 蒋文军[1] Luo Liping;Wang Weidong;Jiang Wenjun(Basic Research Center,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,University of Electronic Science and Technology of China,Chengdu 610041,Sichuan,China;Radiotherapy Center,Radiation Oncology Key Laboratory of Sichuan Province,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,University of Electronic Science and Technology of China,Chengdu 610041,Sichuan,China)

机构地区：[1]四川省肿瘤医院·研究所,四川省肿瘤临床医学研究中心,四川省癌症防治中心,电子科技大学附属肿瘤医院基础研究中心,成都610041 [2]四川省肿瘤医院·研究所,放射肿瘤学四川省重点实验室,四川省肿瘤临床医学研究中心,四川省癌症防治中心,电子科技大学附属肿瘤医院放疗中心,成都610041

出　　处：《肿瘤预防与治疗》2025年第3期237-241,共5页Journal of Cancer Control And Treatment

基　　金：四川省自然科学基金重点项目(编号:2022NSFSC0051);四川省科技厅重点研发项目(编号:2023YFS0089);四川省科技计划项目(编号:2020YJ0446);成都科技创新研发项目(编号:2021YF0501659SN)。

摘　　要：肿瘤精准诊断旨在通过辅助制定个性化治疗方案提升患者治疗效果,并减轻医疗卫生系统的负担。活检技术是癌症诊断的基础,鉴于肿瘤生物学的复杂性,患者通常需接受包括影像学、病理学、基因组学及液体活检在内的多模态诊断流程,以获取更为精确的疾病信息。此外,随着疾病过程的持续和随访的延长,患者医疗数据量激增且呈现高度异构性,这进一步加剧了数据分析的挑战。数字技术的介入为这些难题提供了可行的解决策略,数字活检作为数字技术与医学领域交叉融合的产物,正逐渐演变成推动未来精准医疗发展的关键力量。本综述详细阐述了数字活检的概念、主要分类,以及在肿瘤精准诊疗中的关键优势,并探讨了数字活检的未来发展方向,以期为该领域的深入科研活动与临床实践提供理论参考。Precision diagnosis of tumors aims to enhance treatment outcomes for patients and alleviate the burden on healthcare systems through personalized therapeutic approaches.Biopsy techniques form the cornerstone of cancer diagnosis.Given the complexity of tumor biology,patients often undergo a multimodal diagnostic process involving imaging,pathology,genomics,and liquid biopsies to obtain more precise disease information.Furthermore,with disease progression and extended follow-up,patients'medical data exponentially increases and exhibit high heterogeneity,intensifying the challenges of data analysis.The integration of digital technologies offers feasible solutions to these challenges.Digital biopsy,as a product of the convergence of digital technologies and medicine,is gradually evolving into a key driver of future advancements in precision medicine.This review elaborates on the concept and primary classifications of digital biopsy,highlights its key advantages in the precision diagnosis and treatment of tumors,and discusses its future development directions,aiming to provide theoretical insights for in-depth research and clinical practice in this field.

关 键 词：肿瘤 精准医学 数字活检 影像组学 数字病理 

分 类 号：R737.9[医药卫生—肿瘤]