低位直肠癌患者不同保肛策略治疗后生活质量调查  

Quality of life of patients with low rectal cancer after treatment with different sphincter-preserving strategies

作　　者：彭昕和 朱骥 PENG Xinhe;ZHU Ji(Wenzhou Medical College,Zhejiang Wenzhou 325035,China;Zhejiang Cancer Hospital,Zhejiang Hangzhou 310022,China)

机构地区：[1]温州医科大学,浙江温州325035 [2]浙江省肿瘤医院,浙江杭州310022

出　　处：《现代肿瘤医学》2025年第6期938-945,共8页Journal of Modern Oncology

基　　金：国家卫生健康委员会科研基金(省部共建)(编号:WKJ-ZJ-2305);浙江省科技厅重点研发“尖兵”计划(编号:2022C03015)。

摘　　要：目的:对比直肠癌不同保肛策略治疗后患者的健康相关生活质量。方法:2024年3月21日至2024年4月15日期间,通过浙江省肿瘤医院平台招募接受手术或非手术保肛治疗并已结束治疗的低位直肠癌患者95人,采用欧洲五维健康量表、Wexner肛门失禁评分和国际勃起功能指数分别评估其一般健康状况、控便功能和男性勃起功能。运用Microsoft Excel、SPSS 26.0软件进行统计分析。计数资料以频数、构成比表示;计量资料以平均分表示,组间比较采用Mann-Whitney U检验;组间分类变量的比较采用χ2检验。P<0.05为差异具有统计学意义。结果:回收有效问卷95份。新辅助放化疗后进入观察等待组患者报告的一般健康状况、控便功能均优于新辅助放化疗后保肛手术组,差异具有统计学意义。组间男性勃起功能无显著差异。结论:与手术保肛相比,新辅助治疗后观察等待策略与更好的一般健康状况、控便功能有关。与患者讨论不同保肛策略治疗后患者的健康相关生活质量有助于医患双方共同对保肛治疗策略做出更优选择。Objective:To compare health-related quality of life in patients with rectal cancer treated with different sphincter-preserving strategies.Methods:From March 21,2024 to April 15,2024,95 patients with low rectal cancer who had received surgical or non-surgical sphincter-preserving therapy and had finished the treatment were recruited through the platform of Zhejiang Cancer Hospital.Global health status,defecation control function and male erectile function were evaluated by the EuroQol Five Dimensions Questionnaire,Wexner incontinence score and International Index of Erectile Function.Aggregated survey data were analyzed via Microsoft Excel software and SPSS(Version 26.0).Count data were represented as frequency and constituent ratio.The measurement data were expressed as average scores,and Mann-Whitney U test was used for comparison between groups.The comparison of categorical variables between groups was performed usingχ2 test.P<0.05 was considered statistically significant.Results:95 valid questionnaires were collected.The global health status,defecation control function reported by patients in the Watch&Wait group were better than those in the sphincter-preserving surgery after neoadjuvant chemoradiotherapy group,and there were statistical differences.There was no significant difference in male erectile function between the groups.Conclusion:The Watch&Wait strategy was associated with better global health status and defecation control function than sphincter-preserving surgery after neoadjuvant chemoradiotherapy.Discussing health-related quality of life after treatment with different sphincter-preserving strategies is helpful for both doctors and patients to make a better treatment decision.

关 键 词：直肠癌 患者报告结果 健康相关生活质量 

分 类 号：R735.37[医药卫生—肿瘤]