SETD5在肿瘤干性特征形成中的作用及其机制的研究进展  

Research progress on the role and mechanism of SETD5 in the formation of tumor stemness features

作　　者：孙殿禹 李成浩 SUN Dianyu;LI Chenghao(Department of Gastroenterology,Yanbian University Hospital(Yanbian Hospital),Jilin Yanji 136200,China)

机构地区：[1]延边大学附属医院(延边医院)消化内科,吉林延吉136200

出　　处：《现代肿瘤医学》2025年第6期1039-1043,共5页Journal of Modern Oncology

基　　金：吉林省自然科学基金[面上项目(医学科学领域)](编号:YDZJ202301ZYTS203)。

摘　　要：SET domain-containing protein 5(SETD5)基因作为SET结构域赖氨酸甲基转移酶(lysine methyltransferases,KMTs)家族中的一员,参与了多种细胞功能的调节,涵盖了细胞周期调控、大脑和神经系统发育的指挥以及维持组织内稳态等方面。SETD5还能够通过调控基因表达和染色质状态从而促进肿瘤的发生发展。近年来,SETD5被发现在肿瘤干性特征形成中发挥关键作用,有望成为新的治疗靶点。该文深入探讨了SETD5的结构、功能,重点阐述了SETD5与肿瘤干性特征的关系及调控机制,旨在为肿瘤的诊断和治疗尤其是抑制其干性特征提供新的方法和思路。SET domain-containing protein 5(SETD5),a member of the SET family of structural domain lysine methyltransferases(KMTs),is involved in the regulation of a wide range of cellular functions,including cell cycle regulation,command of brain and nervous system development,and maintenance of intra-tissue homeostasis.SETD5 also promotes tumour development by regulating gene expression and chromatin status.In recent years,SETD5 has been found to play a key role in the formation of tumour stemness characteristics,which is expected to become a new therapeutic target.In this paper,the structure and function of SETD5 are discussed in depth,and the relationship and regulatory mechanism between SETD5 and tumour stemness features are highlighted,aiming to provide new methods and ideas for the diagnosis and treatment of tumours,especially for inhibiting their stemness features.

关 键 词：SETD5 肿瘤干性 缺氧 糖酵解 PI3K/AKT/mTOR通路 

分 类 号：R73[医药卫生—肿瘤]