原发性肝细胞癌新功能靶标发现与靶向诊治技术进展  

Progress on the discovery of new functional targets for hepatocellular carcinoma and development of advanced techniques for its targeted diagnosis and therapy

作　　者：王辰瀚 汪翰林 王欣波 邢信昊 吴元昊 罗萌萌 潘宇飞 董立巍 谈冶雄 黄河 贺晓鹏 王红阳 李佳 Chen-Han Wang;Han-Lin Wang;Xin-Bo Wang;Xin-Hao Xing;Yuan-Hao Wu;Meng-Meng Luo;Yu-Fei Pan;Li-Wei Dong;Ye-Xiong Tan;He Huang;Xiao-Peng He;Hong-Yang Wang;Jia Li(State Key Laboratory of Chemical Biology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering,Feringa Nobel Prize Scientist Joint Research Center,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China;International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute,Naval Medical University,Shanghai 200438,China;National Center for Drug Screening,State Key Laboratory of Chemical Biology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Oncology Pharmacy Laboratory,National Center for Liver Cancer,Naval Medical University,Shanghai 201805,China)

机构地区：[1]中国科学院上海药物研究所,化学生物学研究中心,上海201203 [2]华东理工大学化学与分子工程学院,费林加诺贝尔奖科学家联合研究中心,结构可控先进功能材料及其制备教育部重点实验室,上海200237 [3]中国人民解放军海军军医大学,东方肝胆外科医院,国际合作生物信号转导研究室,上海200438 [4]中国科学院上海药物研究所,国家新药筛选中心,生命过程小分子调控全国重点实验室,上海201203 [5]中国人民解放军海军军医大学,国家肝癌科学中心,肿瘤药学研究室,上海201805

出　　处：《中国科学:化学》2025年第4期892-913,共22页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:92253306)资助项目。

摘　　要：肝细胞癌(HCC)是最常见的原发性肝癌,其在慢性肝脏炎症环境中发生发展,与病毒性肝炎感染或暴露于诸如酒精或黄曲霉毒素等有害环境因素密切相关.本文回顾了HCC在中国人群中的临床现状,梳理了现有诊治策略及其不足之处,系统性总结了早先及近期揭示的HCC细胞信号转导机制,并就以下两类前沿技术进行综述:(1)蛋白质组学技术,挖掘新的功能分子靶标;(2)靶向HCC特异性表达膜蛋白的前沿诊疗技术,以期为HCC的早期、精准诊治提供新的见解.Hepatocellular carcinoma(HCC)is the most common primary liver cancer,which develops in a chronic inflammatory environment of the liver,and is closely related to viral hepatitis infection or exposure to harmful environmental factors such as alcohol or aflatoxins.This article reviews the clinical status of HCC in Chinese population,discusses the existing diagnosis and treatment strategies and their shortcomings,systematically summarizes the early and recent revealed signal transduction mechanisms of HCC cells,and highlights the following two types of cutting-edge techniques:(1)proteomics technology,mining new functional molecular targets;and(2)advanced diagnostic and therapeutic techniques targeting membrane proteins that are specifically expressed by HCC in order to provide new insights for the early and precise diagnosis and effective treatment of HCC.

关 键 词：肝细胞癌 信号转导机制 蛋白质组学 靶向诊疗 

分 类 号：R735.7[医药卫生—肿瘤]