溶酶体在肿瘤发生及转移中的作用研究进展  

Role of lysosomes in tumorigenesis and metastasis

作　　者：范蝶 姚欣怡 孙瑞娟 周欣怡 孙建伟 刘楠 FAN Die;YAO XinYi;SUN RuiJuan;ZHOU XinYi;SUN JianWei;LIU Nan(Yunnan Key Laboratory of Cell Metabolism and Diseases,Center for Life Sciences,School of Life Sciences,Yunnan University,Kunming 650500,China;Department of Thoracic Surgery,Weifang People’s Hospital,Weifang 261000,China)

机构地区：[1]云南大学生命科学学院,生命科学中心,云南省细胞代谢与疾病重点实验室,昆明650500 [2]潍坊市人民医院胸外科,潍坊261000

出　　处：《中国科学:生命科学》2025年第4期742-760,共19页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:82273460,32260167);云南大学研究生科研创新项目(批准号:TM-23236924,ZC-23236399,KC-24249356)资助。

摘　　要：溶酶体作为细胞内主要代谢活动的中心通信枢纽,其功能紊乱与多种疾病发生密切相关,但溶酶体与肿瘤发生的关系仍需进一步探索.肿瘤转移是一个多步骤的过程,包括从原发肿瘤部位逃逸、局部侵袭、体内浸润、在体循环中存活、外渗到远处器官,最后在继发肿瘤部位成功定植和生长,超过90%的癌症患者死于肿瘤远处靶器官转移.已有研究表明,溶酶体在肿瘤转移中发挥重要作用,但其具体机制并不明确.本文综述了溶酶体在肿瘤发生及转移中的作用及机制,为未来开发针对溶酶体的靶向药物,从而预防和治疗肿瘤,提供了借鉴和参考.Lysosomes are crucial for the main metabolic activities within cells,and their dysfunction is linked to various diseases.However,the association between lysosomes and tumor metastasis remains unclear.Tumor metastasis involves escape from the primary tumor site,local invasion,intravasation into circulation,survival in the systemic circulation,extravasation to distant organs,and colonization and growth at secondary tumor sites.Over 90%of cancer-related deaths are attributed to metastasis to distant target organs.The significance of lysosomes in metastasis has been highlighted;however,its underlying mechanisms remain unclear.This review examines the role and mechanisms of lysosomes in tumorigenesis and metastasis and provides insights for targeted therapeutic strategies aiming at lysosomes in cancer prevention and treatment.

关 键 词：溶酶体 组织蛋白酶 溶酶体相关膜蛋白 肿瘤发生 肿瘤转移 

分 类 号：R730.2[医药卫生—肿瘤]