炎症反应在卒中后抑郁中的作用及中药制剂保护作用的研究进展  

Research progress on the role of inflammation in post-stroke depression and the protective effect of Chinese medicine preparations

作　　者：李威 桂茹 孙景萍 蔡学礼[1,2] LI Wei;GUI Ru;SUN Jingping;CAI Xueli(Department of Neurology,Lishui Central Hospital,Lishui,Zhejiang 323000,China;Lishui Clinical Research Center for Neurological Diseases,Lishui,Zhejiang 323000,China)

机构地区：[1]丽水市中心医院神经内科,浙江丽水323000 [2]丽水市神经病学临床研究中心,浙江丽水323000

出　　处：《重庆医学》2025年第4期1000-1004,共5页Chongqing Medical Journal

基　　金：浙江省中医药科技计划项目(2023ZF062)。

摘　　要：炎症反应在卒中后抑郁(PSD)的发生、发展过程中起着重要作用,但是具体的分子机制仍不完全清楚。在药物研究领域,中药制剂可改善PSD症状受到广泛关注,并在预防和治疗该病的临床应用中展现出重要的研究价值。该文从炎症反应的分子机制角度切入,疏理促炎/抗炎因子平衡、炎症标志物表达调控、基因多态性等在PSD中的作用机制,并总结中药制剂调控炎症反应防治PSD相关的最新研究进展,以期为临床中药制剂选择及PSD的防治提供参考。Inflammation plays a crucial role in the occurrence and development of post-stroke depression(PSD),yet the specific molecular mechanisms are still not fully understood.In the field of drug research,traditional Chinese medicine preparations have attracted increasing attention for improving PSD symptoms due to their advantages of multiple targets,many links,and few side effects.At the same time,they have great research value in the prevention and treatment of PSD.This article reviews the mechanism of inflammatory reaction,such as the balance regulation of pro-inflammatory/anti-inflammatory factors,inflammatory markers,gene polymorphism of inflammatory factors in PSD,and the related research progress of Chinese medicine preparations in regulating inflammatory reaction to prevent and treat PSD,with a view to providing reference for the selection of clinical Chinese medicine preparations and the prevention and treatment of PSD.

关 键 词：卒中后抑郁 炎症反应 作用机制 中药制剂 

分 类 号：R741[医药卫生—神经病学与精神病学]