含铋剂四联疗法联合双歧杆菌四联活菌片治疗幽门螺杆菌感染合并肠道菌群失调的效果  

Effect of Bismuth-containing Quadruple Therapy Combined with Bifidobacterium Quadruple Viable Tablet in the Treatment of Helicobacter Pylori Infection Complicated with Intestinal Flora Disturbance

作　　者：雷佳[1] 王飞勇 Lei Jia;Wang Feiyong(Department of Gastroenterology,Bayannur Hospital,Bayannur 015000,Inner Mongolia Autonomous Region,China;Department of Pathology,Bayannur Hospital,Bayannur 015000,Inner Mongolia Autonomous Region,China)

机构地区：[1]巴彦淖尔市医院消化内科,内蒙古自治区巴彦淖尔015000 [2]巴彦淖尔市医院病理科,内蒙古自治区巴彦淖尔015000

出　　处：《中外医药研究》2025年第10期49-51,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨含铋剂四联疗法联合双歧杆菌四联活菌片治疗幽门螺杆菌(Hp)感染合并肠道菌群失调的效果。方法:选取2023年6月—2024年6月巴彦淖尔市医院收治的90例Hp感染合并肠道菌群失调患者为研究对象,随机分为参照组和试验组,每组45例。参照组接受含铋剂四联疗法,试验组在参照组基础上联用双歧杆菌四联活菌片。对比两组Hp根除率、氧化应激指标水平、肠道菌群分布情况。结果:试验组Hp根除率高于参照组(P=0.015)。治疗前,两组谷胱甘肽还原酶、丙二醛、超氧化物歧化酶水平对比,无统计学差异(P>0.05);治疗后,两组谷胱甘肽还原酶、超氧化物歧化酶水平升高,丙二醛水平降低,试验组优于参照组(P<0.05)。治疗前,两组乳杆菌、双歧杆菌、肠杆菌、丁酸梭菌数量对比,无统计学差异(P>0.05);治疗后,两组乳杆菌、双歧杆菌、丁酸梭菌数量增加,肠杆菌数量减少,试验组优于参照组(P<0.05)。结论:含铋剂四联疗法联合双歧杆菌四联活菌片治疗Hp感染合并肠道菌群失调的效果显著,可提高Hp根除率,减轻氧化应激反应,改善肠道菌群分布。Objective:To investigate the effect of bismuth-containing quadruple therapy combined with bifidobacterium quadruple viable tablet in the treatment of Helicobacter pylori(Hp)infection combined with intestinal flora disturbance.Methods:A total of ninety patients with Hp infection complicated with intestinal flora disturbance admitted to Bayannur Hospital from June 2023 to June 2024 were selected as the study objects,and randomly divided into reference group and experimental group,with forty-five cases in each group.The reference group received quadruple therapy containing bismuth,and the experimental group received bifidobacterium quadruple viable tablet based on the reference group.Hp eradication rate,oxidative stress index level and intestinal flora distribution were compared between the two groups.Results:The eradication rate of Hp in experimental group was higher than that in reference group(P=0.015).Before treatment,there were no significant differences in the levels of glutathione reductase,malondialdehyde and superoxide dismutase between the two groups(P>0.05).After treatment,glutathione reductase and superoxide dismutase levels were increased and malondialdehyde levels were decreased in two groups,and the experimental group was better than the reference group(P<0.05).Before treatment,there was no significant difference in the number of lactobacillus,bifidobacterium,enterobacter and clostridium butyricum between the two groups(P>0.05).After treatment,the number of Lactobacillus,bifidobacterium and clostridium butyricum increased and the number of enterobacterium decreased in both groups,and the experimental group was better than the reference group(P<0.05).Conclusion:Bismuthcontaining quadruple therapy combined with bifidobacterium quadruple viable tablets has a significant effect on Hp infection combined with intestinal flora disturbance,which can increase Hp eradication rate,reduce oxidative stress reaction and improve intestinal flora distribution.

关 键 词：幽门螺杆菌感染 肠道菌群失调 双歧杆菌四联活菌片 

分 类 号：R573[医药卫生—消化系统]