血清NSE、CA211、CEA对SCLC患者化疗效果的评估价值  

The value of serum NSE,CA211 and CEA in evaluating the chemotherapy effect of SCLC patients

作　　者：李顺启 LI Shunqi(Medical Laboratory,Xinyang Central Hospital,Xinyang,Henan,464000,China)

机构地区：[1]信阳市中心医学检验科,河南信阳464000

出　　处：《新疆医学》2025年第3期329-332,共4页Xinjiang Medical Journal

摘　　要：目的探究血清神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CA211)、癌胚抗原(CEA)水平评估小细胞肺癌(SCLC)患者化疗效果的价值。方法病例选取为2021年1月~2023年5月收治的76例SCLC患者,均施以EP方案化疗。根据疗效划分为有效组、无效组,比较两组NSE、CA211、CEA在化疗前后的变化;分析NSE、CA211、CEA与SCLC疗效的相关性;ROC曲线评估NSE、CA211、CEA的价值。结果化疗后,SCLC患者血清NSE、CA211、CEA[(18.73±5.11)ng/mL、(4.42±1.39)ng/mL、(21.10±6.19)ng/mL]相较于化疗前[(35.35±7.46)ng/mL、(8.53±2.30)ng/mL、(31.05±6.71)ng/mL]有明显降低(P<0.05)。76例SCLC患者化疗有效39例(51.32%),无效37例(48.68%);化疗后,有效组NSE、CA211、CEA较于无效组更低(P<0.05)。NSE、CA211、CEA与SCLC化疗效果呈负相关(r=-0.460、-0.448、-0.409,均P<0.05)。NSE、CA211、CEA评估化疗效果的AUC分别为0.766、0.758、0.736;敏感度为78.4%、64.9%、73.0%,特异度为66.7%、79.5%、64.1%;三项联合的评估效能最好(AUC=0.925,敏感度92.3%,特异度81.1%)。结论SCLC患者血清NSE、CA211、CEA水平与化疗效果相关,三项联合监测对SCLC疗效有较高评估价值。Objective To explore the value of serum neuron-specific enolase(NSE),cytokeratin 19 fragment(CA211)and carcinoembryonic antigen(CEA)levels in evaluating the efficacy of chemotherapy in patients with small cell lung cancer(SCLC).Methods A total of 76 patients with SCLC who were admitted to our hospital from January 2021 to May 2023 were enrolled in this study.All patients were treated with EP regimen.According to the efficacy,the patients were divided into effective group and ineffective group.The changes of NSE,CA211 and CEA before and after chemotherapy were compared between the two groups.The correlation between NSE,CA211,CEA and the efficacy of SCLC was analyzed.The receiver operating characteristic(ROC)curve was used to evaluate the value of NSE,CA211 and CEA.Results After chemotherapy,The serum levels of NSE,CA211 and CEA in SCLC patients[(18.73±5.11)ng/mL,(4.42±1.39)ng/mL,(21.10±6.19)ng/mL]were significantly lower than those before chemotherapy[(35.35±7.46)ng/mL,(8.53±2.30)ng/mL,(3105±6.71)ng/mL](P<0.05).Among 76 patients with SCLC,39 cases(51.32%)were effective and 37 cases(48.68%)were ineffective.After chemotherapy,The NSE,CA211,CEA in the effective group were lower than those in the ineffective group(P<0.05).NSE,CA211,CEA were negatively correlated with SCLC chemotherapy effect(r=-0.460,-0.448,-0.409,all P<0.05).The AUC of NSE,CA211 and CEA were 0.766,0.758 and 0.736,respectively.The sensitivity was 78.4%,64.9%and 73.0%,and the specificity was 66.7%,79.5%and 64.1%,respectively.The combination of three factors had the best evaluation efficacy(AUC=0.925,sensitivity 92.3%,specificity 81.1%).Conclusions The levels of serum NSE,CA211 and CEA are correlated with the efficacy of chemotherapy in patients with SCLC,and the combined monitoring of the three indexes has a high evaluation value for the efficacy of SCLC.

关 键 词：小细胞肺癌 化疗 神经元特异性烯醇化酶 细胞角蛋白19片段 癌胚抗原 评估价值 

分 类 号：R734.2[医药卫生—肿瘤]