ALK阳性原发性皮肤间变大细胞淋巴瘤一例病理学观察及文献复习  

A case of ALK positive primary cutaneous anaplastic large cell lymphoma:pathological observation and literature review

作　　者：侯晓丽 何慧子 HOU Xiaoli;HE Huizi(Pathology Department,Friendship Hospital of Ili Kazakh Autonomous Prefecture,Ining,Xinjiang Uygur Autonomous Region,835000,China)

机构地区：[1]伊犁哈萨克自治州友谊医院病理科,新疆伊犁835000

出　　处：《新疆医学》2025年第3期378-380,共3页Xinjiang Medical Journal

摘　　要：目的提高ALK阳性原发性皮肤间变大细胞淋巴瘤的认识。方法对1例ALK阳性原发性皮肤间变大细胞淋巴瘤的临床及病理资料进行分析。结果患者平均年龄60岁。临床症状以躯干及四肢皮肤病变较多见,通常表现为孤立性病灶,少数为多灶病变,常伴有溃疡形成且生长迅速。肿瘤细胞弥漫分布,细胞异型、间变,胞质丰富,核圆形、肾形或马蹄形,核仁明显、核分裂像多见。肿瘤细胞CD30、ALK阳性。结论间变性淋巴瘤激酶阳性原发性皮肤间变大细胞淋巴瘤是一种罕见的原发于皮肤的T细胞淋巴瘤,肿瘤细胞具有间变特征。在病理学诊断时要综合考虑患者的临床表现、症状和体征,免疫组化具有重要的诊断价值。Objective To enlarge the knowledge about ALK positive primary cutaneous anaplastic large cell lymphoma(PC-ALCL).Methods The clinical and pathological data of a case with ALK positive primary cutaneous anaplastic large cell lymphoma were analyzed.Results The age of the patients is 60 years old.The clinical symptoms were most commonly seen as skin lesions on the trunk and limbs,typically presenting as an solitary lesions,with a minority being multifocal.Ulceration is often present,and the lesions grow rapidly.Tumor cells are diffusely distributed,exhibiting cellular atypical and pleomorphism,with abundant cytoplasm.The nuclei were round,kidney-shaped,or horseshoe-shaped,with prominent nucleoli and frequent mitotic figures.The Tumor cells are positive for CD30 and ALK.Conclusions ALK positive primary cutaneous anaplastic large cell lymphoma is a rare primary T-cell lymphoma of the skin.Tumor cells exhibit anaplastic features.In pathological diagnosis,the clinical manifestations,symptoms,and signs of the patient should be overall considered,and immunohistochemistry has important diagnostic value.

关 键 词：原发性皮肤间变大细胞淋巴瘤 间变性淋巴瘤激酶 病理学观察 

分 类 号：R739.5[医药卫生—肿瘤]