肝移植治疗儿童肝母细胞瘤的几个应用问题  

Current status and recent advances of liver transplantation for pediatric hepatoblastoma

作　　者：於丙然 陈功[1] Yu Bingran;Chen Gong(Department of Pediatric Surgery,National Children’s Medical Center,Children’s Hospital of Fudan University,Shanghai Key Laboratory of Birth Defects,Shanghai 201102,China)

机构地区：[1]国家儿童医学中心复旦大学附属儿科医院外科,上海201102

出　　处：《临床小儿外科杂志》2025年第3期201-206,共6页Journal of Clinical Pediatric Surgery

基　　金：国家儿童医学中心临床-基础双结对重点项目(EKSJD202409);上海市临床重点专科(shslczdzk05703);2024年医疗服务与保障能力提升(国家临床重点专科建设)项目(10000015Z155080000004)。

摘　　要：肝母细胞瘤是儿童最常见的肝脏原发性恶性肿瘤。尽管早期诊断、手术技术以及以铂类药物为基础的化疗方案均取得了较大进展,但仍有部分患儿的肿瘤在化疗后无法进行手术切除。对于这些晚期或不可切除的肝母细胞瘤,肝移植成为一种有效的治疗选择。近年来,肝移植在儿童肝母细胞瘤治疗中的应用取得了显著进展。本文旨在总结肝移植治疗儿童肝母细胞瘤的现状及进展,讨论肝移植的适应证及禁忌证、治疗策略及其效果,并分析其潜在的并发症。Hepatoblastoma is the most common primary malignant liver tumor in children.Although significant advancements have been made in early diagnosis,surgical techniques,and platinum-based chemotherapy regimens,some tumors remain unresectable even after chemotherapy.For these advanced or unresectable cases,liver transplantation has emerged as an effective treatment option.In recent years,substantial progress has been achieved in applying liver transplantation for pediatric hepatoblastoma.This article aims to summarize the current status and developments in liver transplantation in treating children with hepatoblastoma,discuss indications and contraindications,strategies and outcomes,and analyze potential complications associated with the procedure.

关 键 词：肝母细胞瘤 肝移植 外科手术 预后 儿童 

分 类 号：R735.7[医药卫生—肿瘤]