儿童肾母细胞瘤的临床病理及分子遗传学研究进展  

Clinicopathological characteristics and research advances of pediatric Wilms tumor

作　　者：储婧 Chu Jing(Department of Pathology,Anhui Provincial Children’s Hospital,Hefei 230051,China)

机构地区：[1]安徽省儿童医院病理科,合肥230051

出　　处：《临床小儿外科杂志》2025年第3期296-300,共5页Journal of Clinical Pediatric Surgery

基　　金：安徽医科大学校科研基金(2023xkj218)。

摘　　要：肾母细胞瘤(wilms tumor,WT)是来源于肾胚基细胞的恶性胚胎性肿瘤,具有早期诊断困难、治疗后易复发、部分病理亚型预后差等特点。临床、病理组织学检查和分子遗传学检测在WT的正确诊断、指导治疗和预后评估方面扮演着重要角色。本文就WT临床病理学特征、分子遗传学、诊断、鉴别诊断的研究进展进行综述。Wilms tumor(WT)is a malignant embryonal tumor derived from renal blastoid cells.It is characterized by a difficult early diagnosis,frequent recurrence after treatment and a poor prognosis of some pathological subtypes.A combination of clinical profiling,pathological examination and molecular genetic test is indispensable for making an accurate diagnosis,guiding therapy and prognostic prediction.This review summarized the clinicopathologic features,molecular genetics,diagnosis and differential diagnosis of WT as well as its research advances.

关 键 词：肾母细胞瘤 临床病理 分子遗传学 外科手术 儿童 

分 类 号：R737.11[医药卫生—肿瘤]