益生菌联合预康复模式对慢性乙型肝炎肝硬化患者肠道菌群及症状改善影响  

Effects of probiotics combined with prehabilitation intervention on gut microbiota and symptom improvement in patients with hepatitis B-related liver cirrhosis

作　　者：周雯雯 白晓雨 王婷 ZHOU Wenwen;BAI Xiaoyu;WANG Ting(Department of Infectious Diseases,People's Hospital of Rugao,226500,China)

机构地区：[1]如皋市人民医院感染性疾病科,226500

出　　处：《传染病信息》2025年第2期123-127,143,共6页Infectious Disease Information

摘　　要：目的探讨益生菌联合预康复模式对慢性乙型肝炎(chronic hepatitis B,CHB)肝硬化患者肠道菌群及症状改善的影响。方法选取2021年5月至2023年5月如皋市人民医院收治的共100例CHB肝硬化患者为研究对象,按随机数字表法分成2组,各50例,其中对照组4例失访,2例中途退出研究,最终纳入44例患者,而观察组3例失访,3例中途退出研究,最终纳入44例患者。对照组予以常规护理,观察组在对照组基础上应用预康复模式护理联合服用益生菌。比较2组患者的肠道菌群差异、临床症状消失时间、临床疗效、细胞免疫水平及疾病康复知识掌握情况、生活质量及依从性评分。结果2组干预后观察组肠道菌群指标改善优干预前,且观察组优于对照组(P均<0.05),且观察组临床症状消失时间更短(P均<0.05);干预后观察组疗效总有效率高于对照组(P<0.05);观察组细胞免疫指标水平显著高于对照组(P均<0.05)。观察组疾病相关知识方面的掌握程度优于对照组(P<0.05)。观察组患者生活质量评分均高于对照组(P<0.05)。观察组的康复依从性得分高于对照组(P<0.05)。结论益生菌联合预康复模式是一种有效的治疗策略,它通过改善肠道菌群状态和增强免疫功能,不仅有助于慢性乙型肝炎肝硬化患者的康复,还能提高患者的生活质量。Objective The study investigates how patients with chronic hepatitis B and liver cirrhosis'intestinal flora and symptom improvement are affected by probiotics taken in conjunction with a pre-rehabilitation model.Methods A total of 100 patients with CHB cirrhosis admitted to People's Hospital of Rugao from May 2021 to May 2023 were selected as the study objects and divided into 2 groups with 50 patients each according to random digital table method.In the control group,4 cases were lost to follow-up and 2 cases dropped out of the study,and 44 patients were eventually included;in the observation group,3 cases were lost to fllow-up and 3 cases dropped out of the study,and 44 patients were eventually included.The control group was given routine nursing,and the observation group was given pre-rehabilitation nursing combined with probiotics on the basis of control group.The differences of intestinal flora,duration of clinical symptom disappearance,clinical efficacy,cellular immunity and disease rehabilitation knowledge,quality of life and compliance scores were compared between the two groups.Results The improvement of intestinal flora index in observation group after intervention was better than that before intervention,and observation group was better than control group(P<0.05),and the observation group experienced a shorter duration of clinical symptom disappearance(P<0.05);The total effective rate in the observation group was higher than that in the control group after the intervention(P<0.05),and the level of cellular immunity indexes in the observation group was significantly higher than that in the control group(P<0.05).The observation group exhibited a higher level of mastery in disease-related information compared to the control group(P<0.05).Patients in the observation group had better QOL ratings than those in the control group(P<0.05).The rehabilitation compliance scores in the observation group were higher than that in the control group(P<0.05).Conclusion Probiotics combined with a prehabilitation model is

关 键 词：益生菌 预康复模式 慢性乙型肝炎肝硬化 肠道菌群 

分 类 号：R573.1[医药卫生—消化系统]