肿瘤免疫检查点抑制剂引起皮肤不良反应多学科专家共识(2025版)  

Multi-disciplinary expert consensus on cutaneous adverse events caused by immune checkpoint inhibitors(2025)

作　　者：《肿瘤免疫检查点抑制剂引起皮肤不良反应多学科专家共识(2025版)》编写委员会 杨骥 孙毅 Expert Committee of Multi-disciplinary expert consensus on cutaneous adverse events caused by immune checkpoint inhibitors(2025)(Expert Committee of Multi-disciplinary expert consensus on cutaneous adverse events caused by immune checkpoint inhibitors(2025),Shanghai 200032,China)

机构地区：[1]《肿瘤免疫检查点抑制剂引起皮肤不良反应多学科专家共识(2025版)》编写委员会,上海200032 [2]复旦大学附属中山医院皮肤科

出　　处：《中国临床医学》2025年第2期306-320,F0003,共16页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(82373463,82073436)。

摘　　要：在肿瘤免疫治疗中,免疫检查点抑制剂引起的免疫相关皮肤不良反应是最早出现和最常出现的不良反应,给患者身体和心理带来很大痛苦,处理不及时和不规范甚至会危及生命。免疫相关皮肤不良反应临床表现多样复杂,诊疗存在诸多问题,包括需要决定是否应停用肿瘤免疫治疗。本共识从免疫相关皮肤不良反应分类、临床表现、治疗以及是否停用免疫治疗等多方面系统分析、综合评价和建议,希望对免疫相关皮肤不良反应的规范诊疗提供帮助,同时强调免疫相关不良反应是多器官多系统受累,需同时关注皮肤、心脏、肺、内分泌和消化系统等损伤。Immune-related cutaneous adverse reactions caused by immune checkpoint inhibitors in tumor immunotherapy are the earliest and most common adverse reactions,bringing great pain to patients both physically and psychologically.These adverse reactions can even be life-threatening due to delayed or non-standard treatment.The clinical manifestations of immunerelated cutaneous adverse reactions are diverse and complex,and there are many uncertainties in their diagnosis and treatment,including whether to discontinue tumor immunotherapy.This consensus makes a systematic analysis,comprehensive evaluation and suggestions on the classification,clinical manifestations,and treatment of cutaneous immune-related adverse events,as well as the consideration of whether to discontinue tumor immunotherapy,hoping to provide help for the standardized diagnosis and treatment of cutaneous immune-related adverse events.In this consensus,it is still emphasized that immune-related adverse events usually involve multiple organs and systems,and attention should be given not only to skin damage but also to potential impacts on the heart,lungs,endocrine system,digestive system,and so on.

关 键 词：肿瘤 免疫疗法 药物毒性 免疫检查点抑制剂 免疫相关皮肤不良反应 多学科专家共识 

分 类 号：R730.51[医药卫生—肿瘤]