噬菌体与抗菌剂互作控制食源性细菌耐药性的研究进展  

Advances in Phage-antimicrobial Interactions in the Inhibition of Foodborne Drug Resistant Bacteria

作　　者：黄膺琰 钟乐[1] 程峥 张雪琴 肖乃玉[1] 王红蕾 HUANG Yingyan;ZHONG Le;CHENG Zheng;ZHANG Xueqin;XIAO Naiyu;WANG Honglei(College of Food Science and Technology,Zhongkai University of Agriculture and Engineering,Guangzhou 510225,China)

机构地区：[1]仲恺农业工程学院轻工食品学院,广东广州510225

出　　处：《食品与生物技术学报》2025年第1期24-31,共8页Journal of Food Science and Biotechnology

基　　金：潮州市2023年重点领域研发计划揭榜挂帅项目(202304ZD02);广州市科技计划项目(2024E04J1231,2023A04J1998,2023B01J2001);广州市基础与应用基础研究-优秀博士“续航”项目(2024A04J2301)。

摘　　要：食源性细菌引发的食品安全问题日益严峻,传统抗菌剂的过度使用会加剧细菌的耐药性,对公共健康构成威胁。噬菌体作为一种新型生物抗菌剂,以其特异性和安全性在控制食源性耐药细菌中显示出潜力,但抗菌谱范围较窄限制了其应用。因此,将噬菌体与其他抗菌剂联合使用,在噬菌体的特异性与抗菌剂的广谱性协同作用下可有效克服单独使用的局限性,降低抗菌剂的使用剂量,实现更高效且环保的抗菌效果。作者综述了噬菌体与抗生素、精油、有机酸、纳米粒子、抗菌肽互作控制食源性细菌耐药性的研究进展,对噬菌体与抗菌剂互作的发展趋势及应用前景进行了展望,为进一步解决食源性细菌耐药的问题提供了参考。Food safety issues arising from foodborne bacteria are becoming increasingly severe,and the overuse of conventional antimicrobials exacerbates the emergence of drug-resistant bacteria,thereby posing a serious threat to public health.Given the specificity and safety profile,bacteriophage therapy serves as a novel bioantimicrobial agent for foodborne drug resistant bacteria,demonstrating a promising prospect.However,the narrow antimicrobial spectrum of bacteriophages limits their application.To address this limitation,a synergistic approach that combines bacteriophage therapy with other antimicrobials is being explored.By integrating the specificity of bacteriophages with the broad-spectrum efficacy of antimicrobials,it is possible to effectively overcome the constraints associated with single-agent treatments while also reducing the dosage required for these agents.This strategy can achieve a more efficient and environmentally friendly antimicrobial effect.The recent advancements in research concerning interactions of bacteriophages with antibiotics,essential oils,organic acids,nanoparticles,and antimicrobial peptides for controlling antimicrobial resistance in foodborne bacteria were reviewed.Furthermore,the future trends in development and potential applications of phage-antimicrobial interactions were anticipated,with an aim of providing a reference for further solving the problem of foodborne drug-resistant bacteria and improving antimicrobial efficacy.

关 键 词：噬菌体 食源性细菌 耐药性 生物控制技术 互作关系 

分 类 号：TS201.3[轻工技术与工程—食品科学]