ATG16L1及其在克罗恩病的作用机制研究进展  

Advances in the study of ATG16L1and its mechanism of action in Crohn’s disease

作　　者：唐友志 尤昕 TANG Youzhi;YOU Xin(The First Affiliated Hospital of Hainan Medical University,Haikou 570100,China;Affiliated Sanya Women’s and Children’s Hospital of Hainan Medical University,Sanya,Hainan 572000,China)

机构地区：[1]海南医科大学第一附属医院,海南海口570100 [2]海南医科大学附属三亚妇女儿童医院,海南三亚572000

出　　处：《中国实验诊断学》2025年第4期477-481,共5页Chinese Journal of Laboratory Diagnosis

基　　金：海南省卫生健康科技创新联合项目资助(WSJK2024MS208)。

摘　　要：克罗恩病(Crohn’s disease,CD)是一种慢性炎症性肠病,特征是胃肠道透壁炎症,导致腹痛、腹泻和体质量减轻等症状。自噬在维持宿主对病原体的防御机制以及防止过度炎症反应之间发挥着至关重要的作用,自噬相关基因16L1(Autophagy-related gene 16-like 1,ATG16L1)是自噬过程中发挥重要功能的关键组成部分,大量证据显示ATG16L1及其基因变异与CD易感性及临床表现密切相关,本文就ATG16L1在CD中的作用机制作一综述。Crohn’s disease(CD)is a chronic inflammatory bowel disease characterized by inflammation of the permeable walls of the gastrointestinal tract,leading to symptoms such as abdominal pain,diarrhea,and weight loss.Autophagy plays a crucial role in maintaining host defense mechanisms against pathogens and preventing excessive inflammatory responses.Autophagy-related gene 16-like 1(ATG16L1)is a key component that plays an important function in the autophagy process,and a large body of evidence shows that ATG16L1and its genetic variants are associated with CD.A large amount of evidence shows that ATG16L1and its gene variants are closely related to CD susceptibility and clinical manifestations,and this article provides a review of the mechanism of ATG16L1’s role in CD.

关 键 词：自噬相关基因16L1 自噬 克罗恩病 

分 类 号：R574[医药卫生—消化系统]