犬尿氨酸及其代谢物对抑郁症影响机制研究进展  

Progress in the study of the mechanism of the effect of the kynurenine and its metabolites on depression

作　　者：刘爱江 李广泉 崔然吉 LIU Aijiang;LI Guangquan;CUI Ranji(The Second Hospital of Jilin University,Changchun 130012,China)

机构地区：[1]吉林大学第二医院,吉林长春130012

出　　处：《中国实验诊断学》2025年第4期482-486,共5页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技发展计划(20230204039YY)。

摘　　要：抑郁症在全球范围内严重威胁着人类的身心健康,其发生发展与体内脂质和氨基酸等代谢异常有密切联系。犬尿氨酸及其下游代谢物如犬尿酸、3-羟基犬尿氨酸和犬尿喹啉酸等已证明影响抑郁症的发病过程,表明犬尿氨酸及其代谢物具有作为抑郁症诊断生物标志物的潜力。本文对抑郁症与犬尿氨酸及其代谢物之间的联系进行综述,可能为抑郁症的诊断与治疗提供新思路。Depression is a serious threat to human physical and mental health worldwide,and its development is closely linked to abnormalities in the metabolism of lipids and amino acids in the body.Kynurenine and its downstream metabolites such as kynurenine,3-hydroxykynurenine and kynurenine quinolinic acid have been shown to influence the pathogenesis of depression,suggesting that kynurenine and its metabolites have the potential to be used as biomarkers for the diagnosis of depression.This article provides a review of the association between depression and kynurenine and its metabolites,which may provide new ideas for the diagnosis and treatment of depression.

关 键 词：抑郁症 犬尿氨酸途径 犬尿氨酸 犬尿酸 3-羟基犬尿氨酸 犬尿喹啉酸 

分 类 号：R749.4[医药卫生—神经病学与精神病学]