运动发挥抗炎作用改善神经炎症相关抑郁症的研究进展  

Research Progress in the Anti-Inflammatory Effect of Exercise in Ameliorating Neuroinflammation-Related Depression

作　　者：张志新 郭琪 陈小雨 ZHANG Zhixin;GUO Qi;CHEN Xiaoyu(College of Rehebilitation Sciences,Shanghai University of Medicine and Health Sciences,Shanghai 201318,China;Tianjin Key Laboratory of Exercise Physiology and Sports Medicine,Institute of Sport,Exercise and Health,Tianjin University of Sport,Tianjin 301617,China)

机构地区：[1]上海健康医学院康复学院,上海201318 [2]天津体育学院运动健康学院运动生理学与运动医学重点实验室,天津301617

出　　处：《中国医学科学院学报》2025年第2期191-197,共7页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(82172552);上海市青年科技英才扬帆计划项目(22YF1417900)。

摘　　要：抑郁症是一种由多因素造成的情感障碍性疾病,其发病机制尚不明确。近年研究发现神经炎症与抑郁症存在关联,主要体现在神经炎症与抑郁症的发病机制相互作用,如大脑单胺类神经递质异常、下丘脑-垂体-肾上腺轴失调、神经发生功能失调等。目前,运动作为抗抑郁的手段已经引起广泛关注。本文通过分析相关文献报道,归纳总结运动通过发挥抗炎作用缓解神经炎症,从而改善与情绪相关途径治疗抑郁症,并探究不同运动处方对运动发挥抗炎作用的影响,旨在为与神经炎症相关抑郁症的治疗提供新的科学思路。Depression is an affective disorder caused by multiple factors,and its pathogenesis is still unclear.However,in recent years,studies have found an association between neuroinflammation and depression,which is mainly reflected in the interaction of their pathogeneses,such as abnormalities of monoamine neurotransmitters in the brain,dysregulation of the hypothalamic-pituitary-adrenal axis,and dysfunction of neurogenesis.Currently,exercise as a therapy for depression has attracted widespread attention.By reviewing relevant research reports,this article summarizes that exercise alleviates neuroinflammation by playing an anti-inflammatory role,thus improving the mood-related pathway to treat depression.Furthermore,this article explores the effects of different exercise prescriptions on the anti-inflammatory role of exercise,aiming to provide new scientific ideas for the treatment of depression associated with neuroinflammation.

关 键 词：运动 抑郁症 神经炎症 抗炎 运动处方 

分 类 号：R749[医药卫生—神经病学与精神病学]