Impact of Helicobacter pylori Eradication on Clinical and Laboratory Parameters in Non-alcoholic Fatty Liver Disease Patients:A Systematic Review and Meta-analysis of Randomized Controlled Trials  

作　　者：Fouad Jaber Saqr Alsakarneh Azizullah Beran Tala Alsharaeh Ahmed-Jordan Salahat Abdelrahman Abdelshafi Islam Mohamed Willie Johnson Khaled Elfert Mohammad Jaber Mohammad Almeqdadi Mohamed Ahmed Hassan Ghoz Wendell K.Clarkston John H.Helzberg 

机构地区：[1]Section of Gastroenterology and Hepatology,Baylor College of Medicine,Houston,77030,USA [2]Department of internal medicine,University of Missouri-Kansas City,Kansas City,USA [3]Department of Gastroenterology and Hepatology,Indiana University School of Medicine,Indianapolis,46202,USA [4]Department of Medical Education,Faculty of Medicine,The University of Jordan,Amman,999045,Jordan [5]Department of Medical Education,Faculty of Medicine,Assiut University,Assiut,71515,Egypt [6]Department of Gastroenterology,University of Missouri-Columbia,Columbia,USA [7]Department of Internal Medicine,University of Minnesota Medical Center,Minneapolis,55454,USA [8]Department of Gastroenterology,University of West Virginia,West Virginia,USA [9]Department of Medical Education,Rawalpindi Medical University,Rawalpindi,Pakistan [10]Department of Transplant Hepatobiliary Disease,Lahey Hospital and Medical Center,Burlington,01805,USA [11]Department of Gastroenterology and Hepatology,University of Missouri Kansas City,Kansas City,64108,USA [12]Department of Gastroenterology,University of Maryland,Maryland,USA [13]Department of Gastroenterology and Hepatology,Saint Luke’s Hospital,Kansas City,64108,USA

出　　处：《Current Medical Science》2025年第1期1-10,共10页当代医学科学(英文)

摘　　要：Objective Helicobacter pylori(HP)infection is associated with non-alcoholic fatty liver disease(NAFLD)and insulin resistance;however,the correlation between HP eradication and NAFLD remains controversial.This systematic review and meta-analysis examined the effect of HP treatment on clinical and laboratory parameters in NAFLD patients.Methods We conducted a literature search of the PubMed,Embase,Scopus,and Web of Science databases through Septem-ber 2023 for randomized controlled trials(RCTs)examining the effect of HP treatment on NAFLD patients versus lifestyle changes alone.The primary outcome was the change in steatosis parameters.The secondary endpoints were changes in anthropometric parameters,inflammatory markers(TNF-α),and metabolic parameters(fasting blood glucose,homeostasis model assessment of insulin resistance,AST/ALT,and lipid profile).The random effects model was used to calculate the standardized mean difference(SMD)with associated 95%confidence intervals(CIs)for our desired outcome.Results Four RCTs met our inclusion criteria.A total of 453 patients were included(mean age 42.8 years,58.5%males),228(50.3%)of whom were in the HP eradication group and 225(49.7%)of whom were in the lifestyle modification group.Compared with lifestyle modification alone,HP eradication had a significant effect on reducing liver steatosis and TNF-αlevels(SMD:-0.9;95%CI-14.67,-3.82,I^(2)=0%and SMD:-6.3;95%CI-9.04,-3.56,I^(2)=0%,respectively).No sig-nificant effect on other metabolic parameters was found.Conclusions HP eradication significantly reduced liver steatosis and TNF-αlevels in NAFLD patients.However,HP eradi-cation did not significantly affect other metabolic indices compared to lifestyle changes alone.

关 键 词：Non-alcoholic fatty liver disease Helicobacter pylori Randomized controlled trials Hepatic steatosis Anthropometric measurements Insulin resistance 

分 类 号：R57[医药卫生—消化系统]