儿茶酚氧甲基转移酶基因Val158Met多态性与强迫症关系的荟萃分析  

Meta-analysis of the relationship between catechol-O-methyltransferase gene Val158Met polymorphism and obsessive-compulsive disorder

作　　者：梁燕 唐文新 江小英[1] 王姝琪 Liang Yan;Tang Wenxin;Jiang Xiaoying;Wang Shuqi(Affiliated Mental Health Center&Hangzhou Seventh People′s Hospital,Zhejiang University School of Medicine,Hangzhou 310013,China)

机构地区：[1]浙江大学医学院附属精神卫生中心杭州市第七人民医院,杭州310013

出　　处：《中华精神科杂志》2025年第4期274-284,共11页Chinese Journal of Psychiatry

摘　　要：目的评估儿茶酚氧甲基转移酶(catechol-O-methyltransferase,COMT)基因Val158Met多态性与强迫症患病风险的相关性。方法检索PubMed、Embase、维普和万方数据库截止2023年11月1日发表的有关COMT多态性与强迫症的病例对照研究,包含强迫症患者和健康对照的可用基因型频率。采用Stata11软件进行数据分析,计算合并比值比(odds ratio,OR)和95%CI,检验异质性并评估发表偏倚。结果最终纳入19项研究,共2393例患者和4134名健康对照。总体结果显示COMT基因Val158Met多态性与强迫症有关(等位基因模型:OR=1.10,95%CI:1.02~1.20,P=0.016;纯合子模型:OR=1.25,95%CI:1.05~1.49,P=0.014;隐性模型:OR=1.18,95%CI:1.01~1.37,P=0.040),这种显著关联主要表现在高加索人群中(等位基因模型:OR=1.17,95%CI:1.06~1.30,P=0.003;纯合子模型:OR=1.35,95%CI:1.08~1.67,P=0.008;隐性模型:OR=1.21,95%CI:1.01~1.44,P=0.041;显性模型:OR=1.20,95%CI:1.01~1.43,P=0.040),而在亚洲人群中没有发现。性别分层分析发现Met纯合子与男性强迫症有关(OR=1.75,95%CI:1.00~3.04,P=0.049),而且白人男性患强迫症的风险显著增加(等位基因模型:OR=1.48,95%CI:1.08~2.03,P=0.014;杂合模型:OR=1.41,95%CI:1.03~1.93,P=0.030;显性模型:OR=1.60,95%CI:1.08~2.38,P=0.020)。结论本Meta分析提示COMT基因Val158Met多态性与男性强迫症的易感性有关,特别是在白人男性中。ObjectiveTo quantitatively summarize the catechol-O-methyltransferase(COMT)gene Val158Met polymorphism and the risk of obsessive-compulsive disorder(OCD).MethodsWe searched databases including PubMed,Embase,Weipu and Wanfang for randomized controlled trials(RCTs)investigating the association between COMT gene polymorphisms and OCD up to November 1,2023.Studies that reported genotype frequencies for both OCD patients and general healthy controls were included.Stata11 software was used to calculate pooled odds ratios(OR)with 95%CI,perform heterogeneity test,and assess publication bias.Results19 studies with 2,393 OCD patients and 4,134 healthy controls were included.The overall results showed that the Val158Met polymorphism was associated with OCD patients(allele model:OR=1.10,95%CI:1.02-1.20,P=0.016;homozygote model:OR=1.25,95%CI:1.05-1.49,P=0.014;recessive model:OR=1.18,95%CI:1.01-1.37,P=0.040).In the ethnic-stratified analysis,this significant association was mainly observed in Caucasians(allele model:OR=1.17,95%CI:1.06-1.30,P=0.003;homozygote model:OR=1.35,95%CI:1.08-1.67,P=0.008;recessive model:OR=1.21,95%CI:1.01-1.44,P=0.041;dominant:OR=1.20,95%CI:1.01-1.43 P=0.040),but not in Asians.In gender-stratified analysis,Met-homozygote was associated with male OCD(OR=1.75,95%CI:1.00-3.04,P=0.049).Moreover,the additional analysis found that the risk of OCD was significantly increased in Caucasian males(allele model:OR=1.48,95%CI:1.08-2.03,P=0.014;heterozygote model:OR=1.41,95%CI:1.03-1.93,P=0.030;dominant model:OR=1.60,95%CI:1.08-2.38,P=0.020).ConclusionThis meta-analysis suggests that the COMT gene Val158Met polymorphism is associated with an increased risk of OCD in males,particularly in Caucasian males.

关 键 词：强迫性障碍 儿茶酚氧甲基转移酶 Val158Met 基因多态性 荟萃分析 

分 类 号：R749.7[医药卫生—神经病学与精神病学]