食管癌组织RAP2B、CREB1、RGS16水平联合检测对术后短期预后的预测价值  

Predictive Value of Combined Detection of RAP2B,CREB1 and RGS16 Levels in Esophageal Cancer Tissue for Short-term Prognosis After Surgery

作　　者：李静[1] 常廷民[1] Li Jing;Chang Tingmin(Department of Gastroenterology,The First Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan,453100,China)

机构地区：[1]新乡医学院第一附属医院消化内科,河南新乡453100

出　　处：《黑龙江医学》2025年第8期935-937,941,共4页Heilongjiang Medical Journal

摘　　要：目的:探讨食管癌组织RAS相关蛋白2B(RAP2B)、环磷酸腺苷反应元件结合蛋白1(CREB1)、G蛋白信号调节因子16(RGS16)水平联合检测对术后短期预后的预测价值。方法:选取2021年6月—2024年1月新乡医学院第一附属医院收治的77例食管癌患者作为研究对象,对比患者癌组织及癌旁组织RAP2B、CREB1、RGS16水平,根据术后6个月后不同预后情况分为预后良好组及预后不良组,分析食管癌术后患者预后的影响因素,并分析其联合检测对术后预后的预测价值。结果:食管癌患者癌组织RAP2B、CREB1、RGS16水平均高于癌旁组织,差异均有统计学意义(t=33.863、22.539、61.924,P<0.05);预后不良组患者有淋巴结转移、≥3 cm病灶直径比例均高于预后良好组,RAP2B、CREB1、RGS16水平均高于预后良好组,差异均有统计学意义(χ^(2)=15.188、11.052;t=8.314、6.940、11.506,P<0.05);logistic回归分析结果显示,淋巴结转移、病灶直径、RAP2B、CREB1、RGS16为患者发生预后不良的危险因素(OR=3.720、3.717、2.427、4.616、3.600,P<0.05);绘制接受者操作特性(ROC)曲线结果显示,入院时癌组织RAP2B、CREB1、RGS16水平联合预测预后不良的曲线下面积(AUC)为0.787。结论:食管癌组织RAP2B、CREB1、RGS16表达升高被视为患者预后不良的独立危险因素,早期检测其表达可作为临床预测患者预后的有效生物学标志,辅助临床早期治疗,以尽可能改善患者预后。Objective:To investigate the predictive value of combined detection of RAS-related protein 2B(RAP2B),cyclic AMP response element binding protein 1(CREB1),and G protein signaling regulatory factor 16(RGS16)expression in esophageal cancer tissues for short-term prognosis after surgery.Methods:Patients with esophageal cancer in the hospital from June 2021 to January 2024 were selected as the research object(n=77).The levels of RAP2B,CREB1 and RGS16 in cancer tissues and adjacent tissues were compared.According to the different prognosis after 6 months,the patients were divided into good prognosis group and poor prognosis group.The univariate and multivariate prognostic factors of patients with esophageal cancer after operation were analyzed by cohort analysis,and the predictive value of combined detection for postoperative prognosis was analyzed.Results:The levels of RAP2B,CREB1 and RGS16 in cancer tissues were higher than those in adjacent tissues,with statistically significant difference(t=33.863,22.539,61.924;P<0.05).The proportions of lymph node metastasis and lesion diameter≥3 cm in the poor prognosis group were higher than those in the good prognosis group,and the levels of RAP2B,CREB1 and RGS16 were higher than those in the good prognosis group,with statistically significant difference(χ^(2)=15.188,11.052;t=8.314,6.940,11.506;P<0.05).Logistic regression analysis showed that lymph node metastasis,lesion diameter,RAP2B,CREB1 and RGS16 were risk factors for poor prognosis(OR=3.720,3.717,2.427,4.616,3.600;P<0.05).The ROC curve showed that the AUC of RAP2B,CREB1 and RGS16 combined predicted poor prognosis at admission was 0.787.Conclusion:The increased expression of RAP2B,CREB1 and RGS16 in esophageal cancer tissues is considered an independent risk factor for poor prognosis in patients.Early detection of their expression can be used as an effective biomarker for predicting patient prognosis in clinical practice,assisting early clinical treatment,and improving patient prognosis.

关 键 词：RAS相关蛋白2B 环磷酸腺苷反应元件结合蛋白1 G蛋白信号调节因子16 食管癌 

分 类 号：R735.1[医药卫生—肿瘤]