人体成分与代谢相关脂肪性肝病的相关性:一项横断面研究  

Relationship between body composition and metabolic associated fatty liver disease: a cross-sectional analysis

作　　者：武海环 王龙龙 赵丽[1] 张冰[1] 牟亚楠 张鸽 孙春华[1] WU Haihuan;WANG Longlong;ZHAO Li;ZHANG Bing;MU Yanan;ZHANG Ge;SUN Chunhua(Department of Health Management Center,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China;Physical Education Institute,Qilu Normal University,Jinan 250200,Shandong,China)

机构地区：[1]山东大学齐鲁医院健康管理中心,山东济南250012 [2]齐鲁师范学院体育学院,山东济南250200

出　　处：《山东大学学报(医学版)》2025年第4期19-25,35,共8页Journal of Shandong University:Health Sciences

基　　金：山东省社会科学规划研究项目(22CTYJ10)。

摘　　要：目的探讨健康体检人群人体成分与代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)的关联,为MAFLD的早期预防、早期筛查以及健康干预提供理论依据。方法采用横断面调查研究方法,选取2021年4月至2022年4月的健康体检人员4046例,依据检查结果将研究对象分为MAFLD组(n=1347例)和非MAFLD组(n=2699例),比较两组一般资料、人体成分、实验室检查的差异,并采用二元Logistic回归模型分析影响MAFLD的独立危险因素。结果MAFLD患病率为33.29%(1347/4046),高血压、饮酒、年龄偏大、超重、有中心型肥胖的人群MAFLD的患病率较高,差异均具有统计学意义(P<0.05)。MAFLD组的体质量指数(body mass index,BMI)、体脂率(percent body fat,PBF)、腰臀比(waist-to-hip ratio,WHR)、内脏脂肪面积(visceral fat area,VFA)、上臂围(arm circumference,AC)、体质量、肝功能、血脂、血糖、血压数值均明显高于非MAFLD组,差异均具有统计学意义(P<0.05)。二元Logistic回归分析得出,VFA(OR=1.010,95%CI:1.006~1.014,P<0.001)、TG(OR=2.049,95%CI:1.841~2.279,P<0.001)、AC(OR=1.387,95%CI:1.327~1.449,P<0.001)、WHR(OR=37.925,95%CI:2.866~501.899,P=0.006)、PBF(OR=1.239,95%CI:1.091~1.408,P=0.001)是MAFLD的独立影响因素。结论人体成分分析中的PBF、WHR、VFA、AC与MAFLD具有一定相关性。监测人体成分的变化,减少WHR、降低PBF和VFA,积极控制血脂,对预防MAFLD有重要作用。Objective To explore the association and risk factors between body composition and metabolic associated fatty liver disease(MAFLD),and to provide a theoretical basis for early prevention,screening and intervention of MAFLD.Methods A total of 4,046 healthy physical examiners were selected from April 2021 to April 2022,and the subjects were divided into MAFLD group(n=1,347)and non-MAFLD group(n=2,699)according to the examination results.The differences of general information,body composition and laboratory indices between the two groups were compared.Binary Logistic regression model was used to analyze the independent risk factors for MAFLD.Results The prevalence of MAFLD was 33.29%(1,347/4,046).The prevalence of MAFLD was higher in patients with hypertension,alcohol drinking,older age,overweight and abdominal obesity,with statistical significance(P<0.05).The values of body mass index(BMI),percent body fat(PBF),waist-to-hip ratio(WHR),visceral fat area(VFA),arm circumference(AC),weight,liver function,blood lipid,fasting blood glucose and blood pressure in the MAFLD group were significantly higher than those in the non-MAFLD group,with statistical significance(P<0.05).Binary Logistic regression analysis showed that VFA(OR=1.010,95%CI:1.006-1.014,P<0.001),PBF(OR=1.239,95%CI:1.091-1.408,P=0.001),WHR(OR=37.925,95%CI:2.866-501.899,P=0.006),AC(OR=1.387,95%CI:1.327-1.449,P<0.001),TG(OR=2.049,95%CI:1.841-2.279,P<0.001)were independent influencing factors of MAFLD.Conclusion PBF,WHR,VFA,and AC are recognized as independent determinants of MAFLD.Monitoring changes of body composition,reducing WHR,PBF and VFA,and actively controlling fasting blood lipid level are important in the prevention of MAFLD.

关 键 词：人体成分 代谢相关脂肪性肝病 体脂率 腰臀比 内脏脂肪面积 上臂围 

分 类 号：R575.5[医药卫生—消化系统]