肝硬化患者QT间期研究新进展  

View from specialist:It is creative,and of certain scientific and educational value.

作　　者：李叶 李生浩 王晴晴 张露 LI Ye;LI Shenghao;WANG Qingqing;ZHANG Lu(School of Public Health,Dali University,Dali 671000,China;General Department of Liver Disease,Kunming Third People's Hospital,Kunming,650000,China)

机构地区：[1]大理大学公共卫生学院,云南大理671000 [2]昆明市第三人民医院肝病综合科,云南昆明650000

出　　处：《海南医科大学学报》2025年第8期634-640,共7页Journal of Hainan Medical University

基　　金：国家自然科学基金地区科学基金项目(82260408);云南省教育厅科学研究基金项目(2024J0863);昆明市科技局社会发展与科技惠民计划项目(2023-1-NS-002)。

摘　　要：诸多研究表明,肝硬化可能累及心脏导致患者心功能受损和电生理异常,后者主要表现为QT间期延长,其与病情的严重程度密切相关,并可能对肝硬化患者的预后造成不良影响。但肝硬化患者心脏方面的损害病情往往较隐匿,静息状态下无明显症状,QT间期也不被重视,导致当患者出现QT间期延长时未能及时识别和干预,造成患者在应激状态时出现不同程度的心功能损害,甚至可能危及生命。目前对肝硬化患者QT间期延长的研究较少,现就肝硬化患者QT间期延长的发生率、机制、影响因素、预后等方面进行阐述,以期为进一步深入研究防治策略奠定基础。Many studies have shown that cardiac involvement of cirrhosis may lead to impaired cardiac function and electrophysiological abnormalities in patients,the latter of which is manifested as prolonged QT interval,which is closely related to the severity of the disease and may cause adverse effects on the prognosis of patients with cirrhosis.However,the heart damage in patients with cirrhosis is often insidious,without obvious symptoms in the resting state,and the QT interval is overlooked,leading to the failure to identify and intervene in time when the QT interval extends,resulting in different degrees of cardiac function dam‑age in patients in the stress state,and may even be life-threatening.At present,there are few studies on QT extension in patients with cirrhosis,and the incidence,mechanism,influencing factors and prognosis of QT extension in patients with cirrhosis are expounded,in order to lay a foundation for further research on prevention and treatment strategies.

关 键 词：肝硬化 QT间期 QT间期离散度 肝硬化心肌病 

分 类 号：R575.2[医药卫生—消化系统]