MicroRNA通过自噬调控影响多发性骨髓瘤的发生发展  

MicroRNA-mediated autophagy regulation in the pathogenesis and progression of multiple myeloma

作　　者：马铭帅 张志华[1] MA Mingshuai;ZHANG Zhihua(Department of Hematology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China)

机构地区：[1]承德医学院附属医院血液内科,承德067000

出　　处：《生命的化学》2025年第4期608-614,共7页Chemistry of Life

基　　金：河北省省级科技计划(自然科学基金)项目(H20222406041)。

摘　　要：自噬作为多发性骨髓瘤体内细胞重要的代谢途径之一,不仅可以使多发性骨髓瘤(multiple myeloma,MM)细胞形成自噬性细胞死亡,也可以促进其体内增殖并最终形成相关药物耐药性。越来越多的证据表明,microRNA通过相关机制调控自噬动态参与MM细胞凋亡或增殖的细胞生物学过程,并介导MM临床药物产生耐药性,影响了MM患者无进展生存时间和总体生存率。为深入解析这一过程的分子机制,后续研究已逐步展开,使该领域成为自噬研究的热点之一。本文通过对microRNA在自噬过程中的调控作用及其作为潜在生物标志物的治疗相关用途进行综述,旨在为MM治疗提供新的见解和理论基础。Autophagy,as a crucial metabolic pathway in multiple myeloma(MM)cells,not only induces autophagic cell death but also promotes tumor proliferation and ultimately contributes to drug resistance development.Accumulating evidence demonstrates that microRNA regulates autophagic flux through specific mechanisms,participating in MM cell apoptosis/proliferation dynamics and mediating clinical drug resistance,thereby significantly affecting patients'progression-free survival(PFS)and overall survival(OS)rates.To elucidate the molecular mechanisms underlying this process,recent studies have progressively explored these pathways,establishing it as a research hotspot in autophagy-related oncology.This review systematically summarizes the regulatory roles of microRNA in autophagy processes and their potential applications as biomarkers and therapeutic targets,aiming to provide novel insights and theoretical foundations for MM treatment strategies.

关 键 词：自噬 MICRORNA 多发性骨髓瘤 HIF-1 骨髓微环境 IL-6 

分 类 号：R733.3[医药卫生—肿瘤]