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作 者:李海南 姚剑超 苏泽宇 LI Hainan;YAO Jianchao;SU Zeyu(Yingtan People's Hospital,Yingtan Jiangxi 335500,China)
出 处:《药品评价》2024年第12期1453-1456,共4页Drug Evaluation
摘 要:目的探究吉西他滨膀胱灌注联合经尿道膀胱肿瘤等离子电切术(PKRBt)在非肌层浸润型膀胱癌(NMIBC)患者的治疗效果。方法选取2020年1月至2023年1月鹰潭市人民医院收治的NMIBC患者80例,按随机数字表法分为两组,各40例。两组均行PKRBt治疗,对照组采用表柔比星膀胱灌注,观察组采用吉西他滨膀胱灌注。比较两组临床疗效,肿瘤标志物,可溶性细胞间黏附分子-1(sICAM-1)水平,可溶性血管细胞黏附分子-1(sVCAM-1),不良反应及癌症复发情况。结果相较于对照组(80.00%),观察组治疗总有效率(95.00%)较高。治疗后,观察组癌胚抗原(CEA)、血管内皮生长因子(VEGF)、重组人Dickkopf相关蛋白3(DKK3)、尿纤维蛋白原降解产物(FDP)、sICAM-1及sVCAM-1水平均低于对照组;且术后1年癌症复发率(12.50%)低于对照组(35.00%),均差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论NMIBC患者采用吉西他滨膀胱灌注联合PKRBt治疗效果显著,机体肿瘤标志物水平及sICAM-1、sVCAM-1水平得到显著降低,癌症复发率较低,且较为安全。Objective To explore the effect of gemcitabine intravesical instillation combined with transurethral plasma resection of bladder tumor(PKRBt)in the treatment of non muscle invasive bladder cancer(NMIBC).Methods Eighty patients with NMIBC in Yingtan People's Hospital from January 2020 to January 2023 were selected and randomly divided into two groups,with 40 cases in each group.The control group was intravesically perfused with epirubicin,and the observation group was intravesically perfused with gemcitabine.The clinical efficacy,tumor markers,soluble intercellular adhesion molecule-1(sICAM-1),soluble vascular cell adhesion molecule-1(sVCAM-1),adverse reactions and cancer recurrence were compared between the two groups.Results Compared with the control group(80.00%),the total effective rate of the observation group(95.00%)was higher.After treatment,the levels of carcinoembryonic antigen(CEA),vascular endothelial growth factor(VEGF),recombinant human Dickkopf associated protein 3(Dkk3),urinary fibrinogen degradation product(FDP),sICAM-1 and sVCAM-1 in the observation group were lower than those in the control group.The cancer recurrence rate(12.50%)at 1 year after surgery was lower than that of the control group(35.00%),with statistical difference(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The effect of gemcitabine intravesical instillation combined with PKRBt in the treatment of NMIBC patients is significant,the level of tumor markers and the levels of sICAM-1 and sVCAM-1 are significantly reduced,the recurrence rate of cancer is low,and it is relatively safe.
关 键 词:非肌层浸润性膀胱癌 经尿道膀胱肿瘤等离子电切术 吉西他滨 膀胱灌注
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