葡萄糖转运蛋白在结直肠肿瘤分子影像诊断的研究进展  

Progress in research of glucose transporters in molecular imaging of colorectal tumors

作　　者：邢晓宏 李晓兵 Xiao-Hong Xing;Xiao-Bing Li(Department of Radiology,Fengxian District Central Hospital,Shanghai 201499,China)

机构地区：[1]上海市奉贤区中心医院放射科,上海市201499

出　　处：《世界华人消化杂志》2025年第4期268-275,共8页World Chinese Journal of Digestology

基　　金：奉贤区科委社会类科技发展基金项目,No.奉科20221301.

摘　　要：结直肠癌是我国最常见的消化道恶性肿瘤之一,由于早期诊断困难,其发病率和死亡率逐年增加.分子影像能监测活体内细胞和分子水平的生物学过程,具有潜在的临床诊断和治疗价值.分子影像关键是发展新的成像技术和构建靶向分子探针.葡萄糖转运蛋白(glucose transporter,Glut)是分布于人体各种细胞膜上的蛋白.目前研究认为,Glut1的异常表达与结直肠癌密切相关,其在结直肠癌发生、发展中发挥重要作用,有望成为结直肠癌分子影像的特异性靶点.Colorectal cancer is one of the most common digestive tract malignant tumors in China.Due to the difficulty in early diagnosis,its morbidity and mortality are increasing year by year.Molecular imaging can monitor biological processes at cellular and molecular levels in vivo,having potential clinical diagnosis and treatment value.The key of molecular imaging is to develop new imaging technology and construct targeted molecular probes.Glucose transporters(Glut)are proteins distributed on various cell membranes in the human body.At present,it is believed that the abnormal expression of Glut1 is closely related to colorectal cancer,playing an important role in the occurrence and development of this malignancy.Therefore,Glut1 is expected to become a specific target for molecular imaging of colorectal cancer.

关 键 词：结直肠癌 分子影像 葡萄糖转运蛋白 纳米颗粒 

分 类 号：R735.3[医药卫生—肿瘤]