调气定痫方联合西药治疗气郁痰滞型癫痫临床研究  

Clinical Study on Tiaoqi Dingxian Prescription Combined with Western Medicine for Epilepsy of Qi Constraint and Phlegm Stagnation Type

作　　者：李建锋 余恒旺 LI Jianfeng;YU Hengwang(Maoming Hospital Affiliated to Guangzhou University of Chinese Medicine,Maoming Guangdong 525000,China)

机构地区：[1]广州中医药大学茂名医院脑病科,广东茂名525000

出　　处：《新中医》2025年第8期49-53,共5页New Chinese Medicine

摘　　要：目的:观察调气定痫方联合西药治疗气郁痰滞型癫痫的临床疗效。方法:选取2023年6月—2024年7月广州中医药大学茂名医院收治的气郁痰滞型癫痫60例作为研究对象,按随机数字表法分为对照组与观察组各30例。对照组给予左乙拉西坦治疗,观察组在对照组基础上给予调气定痫方治疗。2组均治疗3个月,评价2组临床疗效、脑电图(EEG)改善情况、癫痫患者生命质量问卷(QOLIE-31)评分、中医证候评分及不良反应发生率。结果:观察组总有效率为93.33%(28/30),对照组为73.33%(22/30),组间比较,差异有统计学意义(P<0.05)。治疗后,2组癫痫发作频率、发作时间均较治疗前降低(P<0.05),且观察组发作频率、发作时间均少于对照组(P<0.05)。治疗后,2组EEG分级均较治疗前改善(P<0.05),且观察组EEG分级改善优于对照组(P<0.05)。治疗后,2组发作担忧、总健康水平、情绪健康、精力、认知功能、药物影响、社会功能等QOLIE-31量表各项评分均较治疗前升高(P<0.05),且观察组各项评分均高于对照组(P<0.05)。治疗后,2组中医证候评分较治疗前降低(P<0.05),且观察组评分低于对照组(P<0.05)。观察组不良反应发生率为6.67%(2/30);对照组为13.33%(4/30),2组比较,差异无统计学意义(P>0.05)。结论:调气定痫方联合左乙拉西坦治疗气郁痰滞型癫痫可提高临床疗效,改善患者症状及生活质量,且安全性良好。Objective:To observe the clinical effect of Tiaoqi Dingxian Prescription combined with western medicine on epilepsy of qi constraint and phlegm stagnation type.Methods:A total of 60 cases of patients of epilepsy of qi constraint and phlegm stagnation type admitted to Maoming Hospital Affiliated to Guangzhou University of Chinese Medicine from June 2023 to July 2024 were selected as the research subjects.They were randomly divided into the control group and the observation group using a random number table method,with 30 cases in each group.The control group was treated with Levetiracetam,while the observation group was treated with Tiaoqi Dingxian Prescription on the basis of the control group.Both groups were treated for three months,and the clinical effficacy,frequency and duration of onset of epilepsy improvement of electroencephalogram(EEG),Quality of Life in Epilepsy Inventory(QOLIE-31)scores,traditional Chinese medicine(TCM)syndrome scores,and incidence of adverse reactions were evaluated in both groups.Results:The total effective rate was 93.33%(28/30)in the observation group,while that of 73.33%(22/30)in the control group,the difference being significant(P<0.05).After treatment,the frequency and duration of onset of epilepsy in both groups were decreased when compared with those before treatment(P<0.05),and the frequency and duration of onset of epilepsy in the observation group were lower than those in the control group(P<0.05).After treatment,the EEG grading of both groups was improved when compared with that before treatment(P<0.05),and the EEG grading in the observation group was better than that in the control group(P<0.05).After treatment,the QOLIE-31 scores in both groups,including anxiety,overall health level,emotional health,energy,cognitive function,medication effects,and social function,were increased when compared with those before treatment(P<0.05),and all scores in the observation group were higher than those in the control group(P<0.05).After treatment,the TCM syndrome scores in both groups

关 键 词：癫痫 气郁痰滞 调气定痫方 左乙拉西坦 癫痫患者生命质量问卷 

分 类 号：R742.1[医药卫生—神经病学与精神病学]