高压氧联合新辅助化疗对进展期胃癌根治术患者NLR和PLR及术后复发的影响  

Effects of hyperbaric oxygen combined with neoadjuvant chemotherapy on NLR,PLR,and postoperative recurrence in patients undergoing radical surgery for advanced gastric cancer

作　　者：宋应明[1] 吴佳慧 王凌锐 席鑫 李科研 张浩东 徐延均 Song Yingming;Wu Jiahui;Wang Lingrui;Xi Xin;Li Keyan;Zhang Haodong;Xu Yanjun(Department of Gastrointestinal Surgery,Peace Hospital Affiliated to Changzhi Medical College,Changzhi 046000,China;The First Clinical College of Changzhi Medical College,Changzhi 046000,China;Department of Medical Insurance,The Second People’s Hospital of Luzhou District,Changzhi(Changzhi Mental Health Center),Changzhi 046000,China)

机构地区：[1]长治医学院附属和平医院胃肠外科,长治046000 [2]长治医学院第一临床学院,长治046000 [3]长治市潞州区第二人民医院(长治市精神卫生中心)医保科,长治046000

出　　处：《中华航海医学与高气压医学杂志》2025年第3期259-264,共6页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：长治医学院附属和平医院科研基金立项项目(HPYJ201937)。

摘　　要：目的探讨高压氧联合新辅助化疗对进展期胃癌根治术患者的临床疗效、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)及术后复发的影响。方法采用随机数字表法将长治医学院附属和平医院2018年5月至2023年6月行胃癌根治术的86例患者分为对照组与研究组,每组43例。对照组术后予以新辅助化疗,研究组在对照组的基础上联合高压氧治疗,比较2组患者的临床疗效、不良反应发生情况、治疗后半年内的肿瘤复发率及治疗前后的癌胚抗原(CEA)和糖类抗原72-4(CA72-4)水平、胃肠激素(胃动素和胃泌素)水平和炎症相关指标[肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)、NLR和PLR]。结果治疗后,研究组的总有效率(65.12%)高于对照组(53.49%),差异有统计学意义(P<0.05);研究组CEA、CA72-4、TNF-α、IL-6、NLR、PLR均低于对照组,胃动素和胃泌素水平高于对照组,差异均有统计学意义(均P<0.05);治疗期间2组不良反应总发生率差异无统计学意义(P>0.05);研究组治疗后半年内的肿瘤复发率(0)低于对照组(9.30%),差异有统计学意义(P<0.05)。结论高压氧联合新辅助化疗用于进展期胃癌根治术患者可有效缓解其病情,抑制肿瘤的发展和机体炎症反应,促进胃肠功能恢复,减少疾病的复发。Objective To investigate the clinical efficacy of hyperbaric oxygen combined with neoadjuvant chemotherapy in patients undergoing radical surgery for advanced gastric cancer,and its impact on neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and postoperative recurrence.Methods Eighty-six patients who underwent radical gastrectomy at the Peace Hospital Affiliated to Changzhi Medical College from May 2018 to June 2023 were randomly divided into a control group and a study group,with 43 cases in each,according to the random number table method.The control group received postoperative neoadjuvant chemotherapy,while the study group additionally received hyperbaric oxygen therapy on the basis of the treatment of the control group.The clinical efficacy,incidence of adverse reactions,tumor recurrence rate within six months post-treatment,and levels of carcinoembryonic antigen(CEA),carbohydrate antigen 72-4(CA72-4),gastrointestinal hormones(motilin and gastrin),and inflammation-related indicators[tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),NLR,and PLR]before and after treatment were compared between the two groups.Results After treatment,the total effective rate in the study group(65.12%)was higher than that in the control group(53.49%),with a statistically significant difference(P<0.05).The levels of CEA,CA72-4,TNF-α,IL-6,NLR,and PLR in the study group were lower than those in the control group,while the levels of motilin and gastrin were higher,all with statistically significant differences(all P<0.05).There was no significant difference in the overall incidence of adverse reactions between the two groups during treatment(P>0.05).The tumor recurrence rate within six months post-treatment in the study group(0)was lower than that in the control group(9.30%),with a statistically significant difference(P<0.05).Conclusion Hyperbaric oxygen combined with neoadjuvant chemotherapy in patients undergoing radical surgery for advanced gastric cancer can effectively alleviate the pathological condi

关 键 词：高压氧 新辅助化疗 进展期胃癌 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 复发率 

分 类 号：R735.2[医药卫生—肿瘤]