多靶点交替经颅直流电刺激治疗帕金森病患者的效果  

Effects of multi-target alternating transcranial direct current stimulation in treatment of patients with Parkinson’s disease

作　　者：方雅娣 FANG Yadi(Department of Neurology of Nanyang Central Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳市中心医院神经内科,河南南阳473000

出　　处：《中国民康医学》2025年第9期95-98,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察多靶点交替经颅直流电刺激(tDCS)治疗帕金森病患者的效果。方法:选取2022年1月至2023年5月该院收治的92例帕金森病患者进行前瞻性研究,按随机数字表法将其分为对照组(n=46)和研究组(n=46)。对照组采用左旋多巴片治疗,研究组在对照组基础上采用多靶点交替tDCS治疗,比较两组治疗前后疾病严重程度[帕金森病综合评定量表(UPDRS)]评分、步态参数(步速、步宽、步频)水平、躯干肌(胸竖脊肌、腹外斜肌、腰竖脊肌、腹直肌)表面肌电振幅水平,以及不良反应发生率。结果:治疗后,两组UPDRS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组步速均大于治疗前,但组间比较,差异无统计学意义(P>0.05),两组步宽、步频均大于治疗前,且研究组大于对照组,差异有统计学意义(P<0.05);两组胸竖脊肌、腹外斜肌表面肌电振幅水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组腰竖脊肌、腹直肌表面肌电振幅水平均低于治疗前,但组间比较,差异无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在左旋多巴片治疗基础上采用多靶点交替tDCS治疗帕金森病患者可提高步宽和步频,以及降低疾病严重程度评分、胸竖脊肌和腹外斜肌表面肌电振幅水平的效果优于单纯左旋多巴片治疗。Objective:To observe effects of multi-target alternating transcranial direct current stimulation(tDCS)in treatment of patients with Parkinson’s disease.Methods:A prospective study was conducted on 92 patients with Parkinson’s disease admitted to this hospital from January 2022 to May 2023.They were divided into control group(n=46)and study group(n=46)by using the random number table method.The control group was treated with Levodopa tablets,while the study group was treated with multi-target alternating tDCS on the basis of that of the control group.The disease severity[unified Parkinson’s disease rating scale(UPDRS)]scores,the gait parameters(pace,step width,step frequency)levels,the trunk muscle(thoracic erector spinae,external oblique abdominal muscle,lumbar erector spinae,rectus abdominis)surface electromyography amplitude levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the UPDRS scores of the two groups were lower than those before the treatment,that in the study group was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the pace of the two groups were greater than those before the treatment,but there was no statistically significant difference between the groups(P>0.05).The step width and step frequency of the two groups were greater than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The average surface electromyographic amplitude levels of the thoracic erector spinae and external oblique abdominal muscles in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The surface electromyography average amplitude levels of lumbar erector spinae and rectus abdominis in the two groups were lower than those before t

关 键 词：帕金森病 经颅直流电刺激 多靶点交替 步态参数 

分 类 号：R742.5[医药卫生—神经病学与精神病学]