血清CEA、NSE、CYFRA21-1水平联合检测对早期肺癌手术患者预后不良的预测价值  

Predictive value of combined detection of serum CEA,NSE and CYFRA21-1 levels for poor prognosis in patients with early lung cancer surgery

作　　者：高理正 高鹏宇 GAO Lizheng;GAO Pengyu(Department of Clinical Laboratory of General Hospital of Zhengzhou Coal Industry(Group)Co.,Ltd.,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州煤炭工业(集团)有限责任公司总医院检验科,河南郑州450000

出　　处：《中国民康医学》2025年第9期135-137,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)水平联合检测对早期肺癌手术患者预后不良的预测价值。方法:回顾性分析2019年5月至2023年6月该院收治的94例早期肺癌患者的临床资料,均行肺叶切除术+纵隔淋巴结清扫治疗,根据患者预后情况将其分为预后良好组(n=75)和预后不良组(n=19)。比较两组血清CEA、NSE、CYFRA21-1水平,采用点二列相关性分析其与早期肺癌手术患者预后不良的相关性,并绘制受试者工作特征(ROC)曲线分析血清CEA、NSE、CYFRA21-1水平单项及联合检测对早期肺癌手术患者预后不良的预测价值。结果:预后不良组血清CEA、NSE、CYFRA21-1水平均高于预后良好组,差异有统计学意义(P<0.05);点二列相关性分析结果显示,血清CEA、NSE、CYFRA21-1水平与早期肺癌手术患者的预后不良均呈正相关(r>0,P<0.05);ROC曲线分析结果显示,血清CEA、NSE、CYFRA21-1水平单项及联合检测预测早期肺癌手术患者预后不良的曲线下面积均≥0.70,均有一定预测价值,且联合检测预测价值最高。结论:血清CEA、NSE、CYFRA21-1水平联合检测对早期肺癌手术患者预后不良的预测价值高于三者单项检测。Objective:To analyze predictive value of combined detection of serum carcinoembryonic antigen(CEA),neuron-specific enolase(NSE)and cyto-keratin 19 fragment antigen 21-1(CYFRA21-1)levels for poor prognosis in patients with early lung cancer surgery.Methods:The clinical data of 94 patients with early lung cancer admitted to the hospital from May 2019 to June 2023 were retrospectively analyzed.All patients underwent lobectomy+mediastinal lymph node dissection.According to the prognosis of these patients,they were divided into good prognosis group(n=75)and poor prognosis group(n=19).The levels of serum CEA,NSE and CYFRA21-1 were compared between the two groups.The correlation between them and the poor prognosis of the patients with early lung cancer surgery were analyzed by point biserial correlation.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of single and combined detection of serum CEA,NSE and CYFRA21-1 levels for poor prognosis in the patients with early lung cancer surgery.Results:The levels of serum CEA,NSE and CYFRA21-1 in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P<0.05).The point biserial correlation showed that the serum CEA,NSE and CYFRA21-1 levels were poor positively correlated with the prognosis of the patients with early lung cancer surgery(r>0,P<0.05).The ROC curve analysis showed that the area under the curve of single and combined detection of serum CEA,NSE and CYFRA21-1 levels in the prediction of poor prognosis of the patients with early lung cancer surgery were≥0.70,all of which had certain predictive value,and the combined detection had the highest predictive value.Conclusions:The predictive value of combined detection of serum CEA,NSE and CYFRA21-1 levels for poor prognosis in the patients with early lung cancer surgery is higher than that of single detection of the three.

关 键 词：早期肺癌 预后不良 神经元特异性烯醇化酶 癌胚抗原 细胞角蛋白19片段抗原21-1 

分 类 号：R734.2[医药卫生—肿瘤]