阿加曲班与替罗非班联合依达拉奉右莰醇治疗急性进展性脑梗死患者的效果比较  

Comparison of effects of Argatroban and Tirofiban combined with Edaravone dexborneol in treatment of patients with acute progressive cerebral infarction

作　　者：刘亚首 李芳芳 LIU Yashou;LI Fangfang(Second Ward of Department of Neurology of Zhoukou Central Hospital,Zhoukou 466000 Henan,China)

机构地区：[1]周口市中心医院神经内科二病区,河南周口466000

出　　处：《中国民康医学》2025年第9期141-144,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较阿加曲班与替罗非班联合依达拉奉右莰醇治疗急性进展性脑梗死(APCI)患者的效果。方法:选取2021年3月至2023年1月该院收治的92例APCI患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各46例。两组均给予常规治疗,在此基础上,对照组予以替罗非班联合依达拉奉右莰醇治疗,观察组予以阿加曲班联合依达拉奉右莰醇治疗。比较两组临床疗效,治疗前后神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、日常生活能力[Barthel指数(BI)]评分、活化部分凝血活酶时间(APTT)、炎性因子[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.65%(44/46),高于对照组的80.43%(37/46),差异有统计学意义(P<0.05);治疗后,两组NIHSS评分均低于治疗前,且观察组低于对照组,两组BI评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组APTT均长于治疗前,且观察组长于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α、hs-CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿加曲班联合依达拉奉右莰醇治疗APCI患者可提高治疗总有效率和日常生活能力评分,降低神经功能缺损评分和炎性因子水平,延长APTT,效果优于替罗非班联合依达拉奉右莰醇治疗。Objective:To compare effects of Argatroban and Tirofiban combined with Edaravone dexborneol in treatment of patients with acute progressive cerebral infarction(APCI).Methods:A prospective study was conducted on 92 APCI patients admitted to the hospital from March 2021 to January 2023.According to the random number table method,they were divided into control group and observation group,46 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Tirofiban combined with Edaravone dexborneol,while the observation group was treated with Argatroban combined with Edaravone dexborneol.The clinical efficacies,the neurological deficit[National Institutes of Health stroke scale(NIHSS)]scores,the activities of daily living[Barthel index(BI)]scores,the activated partial thromboplastin time(APTT),the inflammatory factors[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.65%(44/46),which was higher than 80.43%(37/46)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS scores of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the BI scores of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the APTT levels of the two groups were longer than those before the treatment,that of the observation group was longer than that of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-αand hs-CRP in the two groups were lower than those before the treatment,those in the observation group we

关 键 词：阿加曲班 替罗非班 依达拉奉右莰醇 急性进展性脑梗死 神经功能缺损 日常生活能力 

分 类 号：R735.7[医药卫生—肿瘤]