脑白质高信号Fazekas分级与患者认知功能和神经功能损伤的关系  

Relationship between brain white matter high signal Fazekas grading and cognitive dysfunction and neurological dysfunction of patients

作　　者：王晨 徐靖 付奇 王铭鑫 WANG Chen;XU Jing;FU Qi(Department of Radiology,Lishui Hospital of Traditional Chinese Medicine,Lishui 323000,China)

机构地区：[1]丽水市中医院放射科,浙江丽水323000 [2]昆明市延安医院放射科 [3]上海市长海医院核医学科

出　　处：《全科医学临床与教育》2025年第4期331-333,354,共4页Clinical Education of General Practice

摘　　要：目的探究脑白质高信号Fazekas分级与患者认知功能和神经功能损伤的关系。方法回顾性分析103例脑白质高信号患者资料,所有患者均接受磁共振成像检查,使用Fazekas分级评估病变严重程度,并以此为依据分为轻度组(Fazekas分级1~2分,n=31)、中度组(Fazekas分级3~4分,n=43)、重度组(Fazekas分级5~6分,n=29),比较不同Fazekas分级患者的一般资料、认知功能和神经功能损伤的差异,并进行相关性分析。结果不同Fazekas分级患者的简易智能评估量表(MMSE)、蒙特利尔认知评估量表(Mo CA)、神经功能缺损评分(NIHSS)比较,差异均有统计学意义(F分别=46.22、21.77、34.95,P均<0.05),其中MMSE得分、MoCA得分均为轻度组>中度组>重度组(t分别=5.21、9.31、13.41、5.71、5.06、9.33,P均<0.05),NIHSS得分为轻度组<中度组<重度组(t分别=6.16、6.67,11.81,P均<0.05)。相关性分析结果显示,Fazekas分级与患者MMSE得分、MoCA得分呈负相关(rs分别=-0.54、-0.66,P均<0.05),与NIHSS得分呈正相关(rs=0.74,P<0.05)。结论脑白质高信号Fazekas分级与患者认知功能损伤呈负相关,与神经功能损伤程度呈正相关。Objective To explore the relationship between brain white matter high signal Fazekas grading and cognitive dysfunction and neurological dysfunction of patients.Methods The data of 103 patients with high white matter signal were retrospectively analyzed.All patients underwent magnetic resonance imaging.The severity of lesions was evaluated using Fazekas grading,and were divided into mild group(Fazekas grading 1-2 points,n=31)and moderate group(Fazekas grading 3-4 points,n=43)and severe groups(Fazekas grading 5-6 points,n=29).The differences in general data,cognitive function and neurological dysfunction among patients with different Fazekas grades were compared,and correlation analysis was conducted.Results There were statistically significant differences in mini-mental state examination(MMSE)score,montreal cognitive assessment(MoCA)score and national institutes of health stroke scale(NIHSS)score among patients with different Fazekas grades(F=46.22,21.77,34.95,P<0.05).Among them,for MMSE score and MoCA score,the squence was mild group>moderate group>severe group(t=5.21,9.31,13.41,5.71,5.06,9.33,P<0.05),while for NIHSS score,the sequence was mild group<moderate group<severe group(t=6.16,6.67,11.81,P<0.05).Correlation analysis showed that Fazekas grading was negatively correlated with MMSE score and MoCA score(rs=-0.54,-0.66,P<0.05),while positively correlated with NIHSS score(rs=0.74,P<0.05).Conclusion Brain white matter high signal Fazekas grading is negatively correlated with cognitive dysfunction of patients and positively correlated with the degree of neurological dysfunction.

关 键 词：脑白质高信号 Fazekas分级 认知功能 神经功能损伤 相关性分析 

分 类 号：R743[医药卫生—神经病学与精神病学]