母乳寡糖功能应用及生物制备的研究进展  

Advances in Functional Application and Biological Preparation of Human Milk Oligosaccharides

作　　者：李方华 朱兴浩 杨腾腾 马静 程丽 祝书红 LI Fanghua;ZHU Xinghao;YANG Tengteng;MA Jing;CHENG Li;ZHU Shuhong(Shandong Bailong Chuangyuan Bio-technology Co.,Ltd.,Yucheng 251200)

机构地区：[1]山东百龙创园生物科技股份有限公司,禹城251200

出　　处：《食品工业》2025年第3期188-193,共6页The Food Industry

基　　金：2023年德州市现代产业领军人才工程创新领军人才项目。

摘　　要：母乳寡糖(HMOs)是母乳中的重要生物活性成分,对婴儿的健康成长具有关键作用。文章综述了母乳寡糖在调节婴儿肠道微生物群、促进免疫系统发育、抗感染和抗炎作用,以及对脑部发育的影响等方面的功能研究进展,并探讨了母乳寡糖的生物制备技术,包括酶法合成和发酵法制备的最新进展,分析了母乳寡糖大规模生产面临的挑战和解决方案。通过对相关研究的总结,文章为未来母乳寡糖的功能应用及产业化提供了理论基础和技术支持。Human milk oligosaccharides(HMOs)are important bioactive components in breast milk and play a key role in the healthy growth of infants.In this review,we review the research progress on the functions of breast milk oligosaccharides in regulating infant intestinal microbiota,promoting immune system development,anti-infective and anti-inflammatory effects,and influencing brain development,discuss the latest progress in the biological preparation of human milk oligosaccharides,including enzymatic synthesis and fermentation,and analyze the challenges and solutions for the large-scale production of human milk oligosaccharides.By summarizing the relevant researches,this paper provides a theoretical basis and technical support for the functional application and industrialization of breast milk oligosaccharides in the future.

关 键 词：母乳寡糖 肠道微生物群 免疫系统 生物制备 

分 类 号：TS252.1[轻工技术与工程—农产品加工及贮藏工程]