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作 者:钱真真 迟慧彦[1] 高蕊[1] QIAN Zhenzhen;CHI Huiyan;GAO Rui(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)
出 处:《西部中医药》2025年第4期79-84,共6页Western Journal of Traditional Chinese Medicine
基 金:中国中医科学院科技创新工程(c12021A04701)。
摘 要:目的:基于文献计量学,揭示中药安全性评价及风险防控的研究概貌,为构建中药安全性评价体系及风险防控体系提供参考与建议。方法:以“中药安全性评价”为主题词,通过对CNKI中文数据库进行相关文献的统计,采用文献计量研究方法,以文献年份、著者、发表单位、词频的分布及关键词等为观察点,基于CiteSpace进行可视化知识图谱。结果:纳入文献130篇,最早研究始于1997年,2006年及之后呈现稳步发展趋势,但多集中于综述、思考、建议等;涉及作者416人,发表文章≥2篇的作者仅占15.14%(63/416),文章产出最多者为肖小河;涉及期刊79家,发文量≥2篇的期刊23家(占29.11%);涉及团队较多,以肖小河、谢雁鸣、宋海波、吕爱平等团队为主,文献合著率90.77%(118/130),作者合作度3.20;关键词中与“中药安全性评价”“中药风险防控”等检索关键词共现较频的关键词有“代谢组学”“毒代动力学”“中药化学成分”“作用机制”“炮制工艺”等。结论:关于中药安全性评价及风险防控的研究尚存在进一步发展的空间,各学者间的学术交流合作尚且缺乏,缺乏关于构建中药安全性评价体系及风险防控体系的规范化指南,故亟需构建“一体化、全链条”的中药安全性评价体系及“多级联动”风险防控体系。Objective:To provide the reference and suggestions for the construction of the safety evaluation and risk prevention and control of traditional Chinese medicine by generalizing the researches based on bibliometrics.Methods:The relevant papers were retrieved and collected from CNKI by taking"herbal safety evaluation"as the keywords,a bibliometric analysis was adopted to observe the distribution of year,author,publishing units,word frequency and keywords for the visualization analysis of knowledge graphs based on CiteSpace.Results:All 130 papers were included,with the earliest study beginning in 1997,showing a trend of steady development since 2006 and later,while they were mostly focused on review,thinking and suggestions;all 416 patients were involved,and the authors who has published more than two papers only held 15.14%(63/416),and Xiao Xiaohe was the prolific author;and 79 journals were contained,and 23 journals have published greater than two papers(holding 29.11%);the study has involved many teams,the main one covered Xiao Xiaohe,Xie Yanming,Song Haibo,LYU Aiping,and the co-authorship rate of the literature was 90.77%(118/130),and the cooperation degree of authors was 3.20;The keywords that co-occurred frequently with the terms such as"the safety evaluation""risk prevention and control of traditional Chinese medicine"were"metabonomics""toxicokinetics""herbal chemical ingredients""the mechanism""preparation process".Conclusion:There is still room for further development of the research on safety evaluation and risk prevention and control of traditional Chinese medicine,a lack of academic exchanges and cooperation among scholars,and a lack of guidelines for standardization on the construction of herbal safety evaluation and risk prevention and control,Therefore,it's urgent to build an"integrated,full chain"herbal safety evaluation system and a"multi-level linkage"risk prevention and control system.
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