基于“阴中求阳”理论探讨线粒体与帕金森病的诊治关系  

Exploring the relationship between mitochondria andthe diagnosis and treatment of Parkinson's disease based on the theory of“reinfocing yang from yin”

作　　者：潘柏存 张芳芳 何凯旋 何宇峰[2] PAN Bocun;ZHANG Fangfang;HE Kaixuan(Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine,Zhongshan 528400,China;Zhongshan Hospital of Traditional Chinese Medicine,Zhongshan 528400,China)

机构地区：[1]广州中医药大学附属中山中医院,广东中山528400 [2]中山市中医院,广东中山528400

出　　处：《四川中医》2025年第4期64-68,共5页Journal of Sichuan of Traditional Chinese Medicine

基　　金：2023年度院级研究生及规培医师科研创新项目。

摘　　要：线粒体障碍可导致细胞正常生命活动受到影响。帕金森病的病因之一是多巴胺能神经元变性无法发挥正常功能,这种功能异常的原因可能与线粒体有关。中医古籍将帕金森病归为“颤证”范畴,属于本虚标实之证,以阳气亏虚为本,痰淤阻滞、风阳上扰为标。阳气亏虚日久,应徐徐图之,明代张景岳则提出:“善补阳者,必于阴中求阳”这一理念。从微观层面分析,恢复正常的线粒体结构以及功能,为多巴胺能神经元提供足够能量,从而改善帕金森病患者症状,亦符合张景岳之理念。本文将基于“阴中求阳”理论,探讨线粒体与帕金森病的诊治关系。Mitochondrial dysfunction can lead to compromised normal cellular physiologic function.One of the causes of Parkinson's disease is the inability of dopaminergic neurons to function properly due to degeneration,and the cause of this abnor-mal function may be related to mitochondria.Ancient Chinese medical texts categorize Parkinson's disease as a“tremor syn-drome”,which belongs to the evidence of this deficiency,with the deficiency of yang qi as the basic,phlegm and silt blockage,wind and yang upward disturbance as the standard.Yang deficiency for a long time,should be slowly figure,the Ming Dynasty Zhang Jingyue's concept:“good complementary yang,when the yin in the sun”.From the micro level,restoring normal mito-chondrial structure and function to provide sufficient energy for dopaminergic neurons to improve the symptoms of Parkinson's dis-ease patients is also in line with Zhang Jingyue's concept.Based on the theory of“reinfocing yang from yin”,this article will dis-cuss the relationship between mitochondria and the diagnosis and treatment of Parkinson's disease.

关 键 词：阴中求阳 线粒体 帕金森病 

分 类 号：R229[医药卫生—中医基础理论]