两个基于4-氨基-2,6-二甲氧基嘧啶的铜(Ⅱ)配合物的合成、表征与性质  

Synthesis,Characterization and Properties of Two Coppper(Ⅱ)Complexes Derived from 4-Amino-2,6-Dimethoxypyrimidine

作　　者：许同桃[1,2] 万洪善 杨甜星[1,2] 高敏 王冲[1,2] XU Tongtao;WAN Hongshan;YANG Tianxing;GAO Min;WANG Chong(College of Medicine and Chemical Engineering,Lianyungang Technical College,Lianyungang 222005,China;Jiangsu Provincial Engineering Research Center for Drug Delivery Carrier Materials,Lianyungang 222005,China)

机构地区：[1]连云港职业技术学院医药与化学工程学院,连云港222005 [2]江苏省药物递送载体材料工程研究中心,连云港222005

出　　处：《人工晶体学报》2025年第4期684-692,共9页Journal of Synthetic Crystals

基　　金：江苏省高等学校基础科学(自然科学)研究面向项目(23KJD530003);江苏省高等教育教学改革研究项目(2023JSJG750)。

摘　　要：以4-氨基-2,6-二甲氧基嘧啶(amp)、有机多胺N-(2-氨基乙基)-1,3-丙二胺(L1)、(二(3-氨基丙基)胺(L2)和铜盐为原料,采用溶剂法自组装合成两种新型铜(Ⅱ)配合物,即[Cu(amp)Lx](ClO_(4))_(2)(x=1,2)。采用元素分析、红外光谱、紫外光谱、粉末X射线衍射,以及扫描电子显微镜等手段对产物进行结构表征。利用单晶X射线衍射法首次解析了[Cu(amp)L2](ClO_(4))_(2)的晶体结构,结果表明其为单斜晶系,P2_(1)/c空间群,a=1.20790(12)nm,b=1.32791(13)nm,c=1.39039(14)nm,a=90°,b=90.056(3)°,γ=90°。荧光光谱表明,配体amp发射波长为387 nm,有较强的荧光值;但与有机多胺及铜(Ⅱ)配位后,出现了显著的荧光淬灭现象,说明amp与有机多胺(L1,L2)具有潜在铜离子荧光探针功能。同时,采用琼脂平板扩散法研究了铜(Ⅱ)配合物体外抑菌活性,结果表明它们对受试微生物具有很好的抑菌作用。Two new copper(Ⅱ)complexes[Cu(amp)Lx](ClO_(4))_(2)(x=1,2)were synthesized by self-assemble of 4-amino-2,6-dimethoxypyrimidine(amp),organic polyamine N-(2-aminoethyl)-1,3-propylamine)(L1),(bi(3-aminopropyl)-amine(L2)and copper salt using the solvent method.The products were characterized by means of elemental analysis,infrared spectroscopy,ultraviolet spectroscopy,powder X-ray diffraction,and scanning electron microscopy.The crystal structure of[Cu(amp)L2](ClO_(4))_(2)was analyzed by single crystal X-ray diffraction.The results indicates that[Cu(amp)L2](ClO_(4))_(2)belongs to monoclinic system,space group P2_(1)/c with a=1.20790(12)nm,b=1.32791(13)nm,c=1.39039(14)nm,a=90°,b=90.056(3)°,γ=90°.In addition,the fluorescence spectrum shows that the ligand amp has an emission wavelength of 387 nm with a strong fluorescence value.However,when the amp coordinates with orgnic polyamines and copper to form a complex,significant fluorescence quenching occurs.This phenomenon indicates that amp interacting with the organic polyamines(L1,L2)have potential functions as fluorescent probes for copper ions.The antibacterial activity of the products in vitro were studied by agar plate diffusion method.The results show that the products have good antibacterial activity against the tested microorganisms.

关 键 词：4-氨基-2.6-二甲氧基嘧啶 有机多胺 铜配合物 荧光性质 晶体结构 抑菌活性 

分 类 号：O614.121[理学—无机化学]