基于cGAS-STING通路和突触融合蛋白17介导的自噬在脑缺血再灌注损伤中的作用研究进展  

Research Progress on the Role of cGAS-STING Pathway and Syntaxin 17 Mediated Autophagy in Cerebral Ischemia-Reperfusion Injury

作　　者：杨航 高安邦 倪莹 马跃 高名同 YANG Hang;GAO Anbang;NI Ying;MA Yue;GAO Mingtong(School of Clinical Medicine,Shandong Second Medical University,Weifang 261035,China;Department of Emergency,Affiliated Hospital of Shandong Second Medical University,Weifang 261035,China)

机构地区：[1]山东第二医科大学临床医学院,潍坊261035 [2]山东第二医科大学附属医院急诊科

出　　处：《中国卒中杂志》2025年第4期479-485,共7页Chinese Journal of Stroke

基　　金：潍坊市卫生健康委员会科研项目(WFWJWK-2024-180)。

摘　　要：急性缺血性卒中后,脑缺血再灌注损伤(cerebral ischemia-reperfusion injury,CIRI)可进一步损伤患者的神经功能,影响其预后。自噬在CIRI的病理过程中是一把“双刃剑”,其不同的激活程度以及在CIRI的不同时期,可对脑组织产生保护或损伤的相反作用。环鸟苷酸-腺苷酸合酶(cyclic guanosine monophosphate-adenosine monophosphate synthase,cGAS)-干扰素基因刺激因子(stimulator of interferon gene,STING)通路是先天免疫中重要的效应通路,突触融合蛋白17(syntaxin 17,STX17)是可溶性N-乙基顺丁烯二酰亚胺敏感性因子附着蛋白受体亚家族成员,两者在CIRI过程中对细胞自噬和线粒体自噬均具有重要的调节作用。本文对cGAS-STING通路和STX17在CIRI中调控自噬的机制及其相互关系进行综述,以期为CIRI的干预提供新的思路和依据。After acute ischemic stroke,cerebral ischemia-reperfusion injury(CIRI)can further damage the neurological function of patients and affect their prognosis.Autophagy is a“double-edged sword”in the pathological process of CIRI.The varying stages and degrees of activation of CIRI can have opposing effects,either protecting or damaging brain tissue.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon gene(STING)pathway is an important pattern recognition and effector pathway in the innate immune response.Syntaxin 17(STX17)is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor subfamily.Both play significant regulatory roles in autophagy and mitophagy during the CIRI process.This article reviews the mechanisms and interrelationships between the cGAS-STING pathway and STX17 in regulating autophagy during CIRI,aiming to provide new ideas and evidence for the intervention of CIRI.

关 键 词：环鸟苷酸-腺苷酸合酶-干扰素基因刺激因子通路 突触融合蛋白17 自噬 脑缺血再灌注损伤 

分 类 号：R74[医药卫生—神经病学与精神病学]