基于rs-fMRI图论方法分析克罗恩病伴慢性腹痛患者的脑功能网络特征  

Analysis of characteristics of brain functional network in Crohn's disease patients with chronic abdominal pain based on rs-fMRI graph theory

作　　者：吴欣妍 杨玲[2,3] 余丽 唐开强 张玲琴 刘念 李康[1,2,3] WU Xinyan;YANG Ling;YU Li;TANG Kaiqiang;ZHANG Lingqin;LIU Nian;LI Kang(Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Department of Radiology,Chongqing General Hospital,Chongqing University,Chongqing,401147,China;Department of Radiology,Chongqing General Hospital,Chongqing,401147,China)

机构地区：[1]川北医学院附属医院放射科,南充637000 [2]重庆大学附属人民医院放射科,重庆401147 [3]重庆市人民医院放射科,重庆401147

出　　处：《磁共振成像》2025年第4期12-18,113,共8页Chinese Journal of Magnetic Resonance Imaging

基　　金：重庆市科技创新重大研发项目(编号:CSTB2024TIAD-STX0045)。

摘　　要：目的 通过静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)结合图论分析方法探究克罗恩病(crohn's disease,CD)患者的慢性疼痛神经网络拓扑属性特征性改变。材料与方法 研究共纳入CD伴慢性腹痛(abdominal pain CD,APCD)患者20例(APCD组),CD不伴腹痛(abdominal pain-free CD,FAPCD)患者24例(FAPCD组),健康对照(healthy controls,HC)30例(HC组)。采集所有被试的rs-fMRI数据及3D-T1数据,记录相关临床量表评分及临床相关指标。比较组间功能网络拓扑指标,分析差异脑区与临床量表评分的相关性。结果 对于全局指标,与APCD组相比,FAPCD组的小世界属性和标准化聚类系数更低(P<0.05),而APCD组、FAPCD组分别与HC组相比差异无统计学意义(P>0.05);对于节点指标,与HC组相比,APCD组在右侧前扣带与旁扣带回的度中心性(degree centrality,DC)增高(均P<0.05),FAPCD组的DC与节点效率(nodal efficiency,NE)在左侧枕上回、右侧中央后回降低(均P<0.05);与FAPCD组相比,APCD组眶部额叶范围内的NE更低,左侧中央前回的DC更高(均P<0.05)。此外,全部CD患者视觉模拟量表评分的增高与左侧中央前回DC增加有关(r=0.386,P<0.05)。结论 APCD患者的脑功能网络拓扑特征发生了改变,特别是在特定脑区的DC和NE方面,这些变化可能为疼痛管理和神经机制的深入研究提供了新的方向。Objective:To explore the characteristic changes in the topological properties of the chronic pain-related neural network in patients with Crohn's disease(CD) using resting-state functional magnetic resonance imaging(rs-fMRI) combined with graph theory analysis.Materials and Methods:A total of 20 chronic abdominal pain CD patients(APCD),24 abdominal pain-free CD patients(FAPCD),and 30 healthy controls(HC) were included.Rs-fMRI and 3D-T1 data were collected from all subjects,and relevant clinical scale scores and clinical indicators were recorded.The topological indices of the functional network were compared among the three groups,and the correlations between the differences in brain regions and clinical scale scores were analyzed.Results:Regarding global metrics,the FAPCD group exhibited lower small-worldness and normalized clustering coefficients compared to the APCD group(P <0.05);however,neither the APCD group nor the FAPCD group showed significant differences when compared to the HC group(P >0.05).Regarding nodal metrics,compared with the HC group,the degree centrality(DC) in the right anterior cingulate and paracingulate gyrus was significantly increased in the APCD group(P < 0.05).The DC and nodal efficiency(NE) in the left superior occipital gyrus and right postcentral gyrus were significantly decreased in the FAPCD group compared with the HC group(P < 0.05).Compared with the FAPCD group,the NE in the orbitofrontal region and the DC in the left precentral gyrus were lower in the APCD group(P < 0.05).Additionally,in APCD and FAPCD two combined CD groups,the increase in the visual analogue scale score for pain was associated with an increase in the DC of the left precentral gyrus(r = 0.386,P < 0.05).Conclusions:The brain network topology characteristics of CD patients with chronic abdominal pain have changed,especially in DC and NE in specific brain regions.These changes may provide new directions for pain management and further research into the underlying neural mechanisms.

关 键 词：克罗恩病 腹痛 图论 脑网络 静息态功能磁共振成像 脑肠轴 

分 类 号：R445.2[医药卫生—影像医学与核医学] R747.9[医药卫生—诊断学]