硫酸镁钠钾口服用浓溶液与聚乙二醇电解质散结肠镜肠道准备的效果对比:基于倾向评分匹配的队列研究  

Comparison of bowel preparation for colonoscopy between oral sulfate solution and polyethylene glycol electrolytes powder:a cohort study based propensity score matching

作　　者：正丽君 郭甜甜[1] 张瑞晓 王月梅 李悦莹 张超[1] 李慧艳 徐颢 杨琦 Zheng Lijun;Guo Tiantian;Zhang Ruixiao;Wang Yuemei;Li Yueying;Zhang Chao;Li Huiyan;Xu Hao;Yang Qi(Department of Gastroenterology,the Affiliated Hospital of Northwest University(the Third Hospital of Xi'an),Xi'an,Shaanxi 710000,China)

机构地区：[1]西北大学附属医院(西安市第三医院)消化内科,陕西西安710000

出　　处：《中国内镜杂志》2025年第4期18-24,共7页China Journal of Endoscopy

摘　　要：目的对比小剂量硫酸镁钠钾口服用浓溶液(OSS)与聚乙二醇(PEG)电解质散在结肠镜检查肠道准备中的清洁效果、患者接受度和安全性。方法本研究为前瞻性、单盲和单中心队列研究。纳入2023年4月-2024年1月于该院行结肠镜检查的门诊和住院患者1037例,根据患者口服的清肠药物不同,分为OSS组(639例)和PEG组(398例),进行倾向评分匹配(PSM)后,两组各385例。比较两组患者肠道准备成功率、波士顿肠道准备量表(BBPS)评分、服药口感、患者满意度和不良反应发生情况。结果OSS组肠道准备成功率为96.4%(371/385),高于PEG组的91.7%(353/385),差异有统计学意义(P<0.05)。OSS组肠道的BBPS总评分和分段评分均高于PEG组(P<0.05)。OSS组的服药口感和患者满意度均明显优于PEG组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P=0.800)。结论相比于PEG电解质散,OSS的肠道清洁效果更好,服药口感更佳,患者接受度更高,且安全性与PEG电解质散相当。Objective To compare the efficacy,acceptability and safety of a low-volume magnisium sodicum potassium sulfate oral sulfate solution(OSS)with polyethylene glycol(PEG)electrolytes powder in bowel preparation for colonoscopy.Methods A prospective,single-blinded and single-center cohort study was conducted.The ambulatory and hospitalized 1037 patients who underwent colonoscopy from April 2023 to January 2024 were enrolled.Participants were divided into OSS group(639 cases)and PEG group(398 cases),according to the bowel cleansing drugs taken orally.After propensity score matching(PSM),each group included 385 cases.The success rate of bowel preparation,scores of Boston bowel preparation scale(BBPS),medication taste,patients'satisfaction and the occurrence of adverse events were compared.Results The success rate of bowel preparation in the OSS group was 96.4%(371/385),higher than the 91.7%(353/385)in the PEG group,and the difference was statistically significant(P<0.05).The total and segmented BBPS scores of the OSS group were higher than those of the PEG group,the differences were statistically significant(P<0.05).The medication taste and patients satisfaction of the OSS group were significantly better than those of the PEG group,the differences were statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P=0.800).Conclusion Compared to PEG,OSS has a better intestinal cleaning effect,medication taste,and patients satisfaction.In addition,OSS has security that is not inferior to PEG.

关 键 词：硫酸镁钠钾口服用溶溶液(OSS) 聚乙二醇(PEG)电解质散 结肠镜检查 肠道准备 倾向评分匹配(PSM) 

分 类 号：R574[医药卫生—消化系统]